VIOLIN: Vaccine Investigation and Online Information Network

cjaA
Gene Name	cjaA
Sequence Strain (Species/Organism)	Campylobacter jejuni RM1221
VO ID	VO_0010955
NCBI Gene ID	3231573
NCBI Protein GI	1813949
Locus Tag	CJE1064
Genbank Accession	CP000025
Protein Accession	YP_179057
Other Database IDs	CDD:270412 GOA:P94643 InterPro: IPR001638 UniProtKB/TrEMBL: P94643
Taxonomy ID	197
Gene Starting Position	993662
Gene Ending Position	994501
Gene Strand (Orientation)	-
Protein Name	surface antigen, CjaA
Protein pI	4.9
Protein Weight	29158.88
Protein Length	324
Protein Note	Substrate binding domain of ABC cysteine transporter; the type 2 periplasmic binding protein fold; cd13694
DNA Sequence	>NC_003912.7:993662-994501 Campylobacter jejuni RM1221, complete genome ATTAAATTTTTCCACCTTCAATCACTACATCATCAGCCTTAACATCATCTCCAAAATGAGCTTTTAAAGT TTCATCATAAGCCTTGTGAAAAAACTGCTCTTGGCCTAGTTTAATGATCAAATTATCGATAAATTCTTTA AGTTCTTTATCGCCTTTTTTAACCGCTGGTGCGATAACATCTTTGTTACCTAACTCTTTGATACCCATTT TAAAATCAGGATGATCTTTCACCCAAGCAAAAAGCAAGGTATTATCATGACTTAAAGCATCGCCTCTTTT ATCCATCAAAGCGGCAAAGGTTTCGGTATTTTGATCATATTTTAAAGTTTTAATATTAGGATAATTTTGC GTAAAATAAGCATCTGCTGTTGTACCTTTGTTTAAAAGCAAGGTTTTATCTTTTAAATCTTCTACGCTAG TTATATTACTATCCTTTGGTACAGCTACGCCTAAAGCTACCTTCATATAAGGCAAGCAAAAATCAACCTG TTCTGCCCTTTGCGGAGTTTGAGTAAAATTAGCCAAAATAATATCTACTTTATTTGATTTTAAAAACTCA ACCCTATTTGCAGCTTCAACAAGAACAAATTGCACCTTATTTTCATCGCCAAAAAGTTCTTTTGCTATGC GTTTAGCTAAAGCTATATCATAGCCTTGATTGTTTCCTTTTTCATCTACATAACCAAAAGGTGGTTTATC GCCAAATACCCCAATCCTAACAACTCCATTTTGCTTGATCTTATCAAGAGAATTTAAAGTTTTAGAGTCA GAATTTCCTCCACAAGCAGCCAATACTACTGCAACAAAGGTCGTTAAAACACTTAGAAGTATTTTTTTCA
Protein Sequence	>CAA71822.1 cjaA [Campylobacter jejuni] MKKMLLSIFTTFVAVFLAACGGNSDSGASNSLERIKQDGVVRIGVFGDKPPFGYVDEKGVNQGYDIVLAK RIAKELLGDENKVQFVLVEAANRVEFLKSNKVDIILANFTQTPERAEQVDFCLPYMKVALGVAVPQDSNI SSIEDLKDKTLLLNKGTTADAYFTKEYPDIKTLKYDQNTETFAALIDQRGDALSHDNTLLFAWVKEHPEF KMAIKELGNKDVIAPAVKKGDKELKEFIDNLITKLGEEQFFHKAYDETLKSHFGDDVKADDVVIEGGKI
Molecule Role	Protective antigen
Molecule Role Annotation	A total of 840 Light Sussex chickens were used to evaluate a Salmonella enterica serovar Typhimurium DeltaaroA vaccine expressing the C. jejuni amino acid binding protein CjaA. Chickens were given the vaccine at 1-day-old and two weeks later by oral gavage, then challenged after a further two weeks with C. jejuni. Across six biological replicates, statistically significant reductions in caecal C. jejuni of c. 1.4log(10) colony-forming units/g were observed at three and four weeks post-challenge relative to age-matched unvaccinated birds. Protection was associated with the induction of CjaA-specific serum IgY and biliary IgA (Buckley et al., 2010).
Related Vaccines(s)	Avirulent Salmonella vaccine strain carrying C. jejuni cjaA gene
References

cjaA