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SodA
Gene Name	SodA
Sequence Strain (Species/Organism)	Mycobacterium tuberculosis H37Rv
NCBI Gene ID	886174
NCBI Protein GI	15610982
Locus Tag	Rv3846
Genbank Accession	NC_000962.2
Protein Accession	NC_000962.2
Other Database IDs	EMBL: AE000516 EMBL: AF061030 EMBL: BX842584 EMBL: X52861 Gene3D: G3DSA:3.90.149.10 GenomeReviews: AE000516_GR GenomeReviews: AL123456_GR InterPro: IPR001189 KEGG: mtc:MT3960 KEGG: mtu:Rv3846 LinkHub: P17670 PANTHER: PTHR11404 PDB: 1GN2 PDB: 1GN3 PDB: 1GN4 PDB: 1GN6 PDB: 1IDS Pfam: PF00081 Pfam: PF02777 PIR: S15205 PRINTS: PR01703 ProDom: PD000475 PROSITE: PS00088 TIGR: MT3960 TubercuList: Rv3846 UniProt: P17670
Taxonomy ID	1773
Gene Starting Position	4320704
Gene Ending Position	4321327
Gene Strand (Orientation)	+
Protein Name	SUPEROXIDE DISMUTASE [FE] SODA
Protein pI	6.43
Protein Weight	23033.8
Protein Length	207
Protein Note	Rv3846, (MTCY01A6.22c), len: 207 aa. sodA (alternate gene names: sodB, sod), superoxyde dismutase (EC 1.15.1.1) (see citations below), equivalent to many e.g. P47201\|SODM_MYCAV\|SODA\|SOD from Mycobacterium avium (206 aa), FASTA scores: opt: 1210, E(): 1.8e-73, (82.5% identity in 206 aa overlap); Q9F9R1\|SOD from Mycobacterium paratuberculosis (207 aa), FASTA scores: opt: 1207, E(): 2.9e-73, (81.65% identity in 207 aa overlap); O86165\|SODM_MYCLP\|SODA\|SOD from Mycobacterium lepraemurium (206 aa), FASTA scores: opt: 1204, E(): 4.5e-73, (82.05% identity in 206 aa overlap); P13367\|SODM_MYCLE\|SODA\|ML0072 from Mycobacterium leprae (206 aa), FASTA scores: opt: 1169, E(): 9.6e-71, (80.5% identity in 205 aa overlap); etc. Contains PS00088 Manganese and iron superoxide dismutases signature. BELONGS TO THE IRON/MANGANESE SUPEROXIDE DISMUTASE FAMILY. ALTHOUGH FOUND EXTRACELLULARLY, NO SIGNAL SEQUENCE IS PRESENT. AN ALTERNATIVE SECRETORY PATHWAY MAY BE USED.; sodB; sod
Protein Annotation	FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems (UniProt: P17670) CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2) (UniProt: P17670) COFACTOR: Binds 1 iron ion per subunit (UniProt: P17670) SUBUNIT: Homotetramer (UniProt: P17670) SUBCELLULAR LOCATION: Secreted protein (UniProt: P17670) SIMILARITY: Belongs to the iron/manganese superoxide dismutase family (UniProt: P17670) CAUTION: Although found extracellularly, no signal sequence is present. An alternative secretory pathway may be used (UniProt: P17670)
DNA Sequence	>GeneID\|886174 [Mycobacterium tuberculosis H37Rv ] 4320704..4321327 gtggccgaatacaccttgccagacctggactgggactacggagcactggaaccgcacatctcgggtcaga tcaacgagcttcaccacagcaagcaccacgccacctacgtaaagggcgccaatgacgccgtcgccaaact cgaagaggcgcgcgccaaggaagatcactcagcgatcttgctgaacgaaaagaatctagctttcaacctc gccggccacgtcaatcacaccatctggtggaagaacctgtcgcctaacggtggtgacaagcccaccggcg aactcgccgcagccatcgccgacgcgttcggttcgttcgacaagttccgtgcgcagttccacgcggccgc taccaccgtgcaggggtcgggctgggcggcactgggctgggacacactcggcaacaagctgctgatattc caggtttacgaccaccagacgaacttcccgctaggcattgttccgctgctgctgctcgacatgtgggaac acgccttctacctgcagtacaagaacgtcaaagtcgactttgccaaggcgttttggaacgtcgtgaactg ggccgatgtgcagtcacggtatgcggccgcgacctcgcagaccaaggggttgatattcggctga
Protein Sequence	>gi\|15610982\|ref\|NP_218363.1\| SUPEROXIDE DISMUTASE [FE] SODA [Mycobacterium tuberculosis H37Rv ] MAEYTLPDLDWDYGALEPHISGQINELHHSKHHATYVKGANDAVAKLEEARAKEDHSAILLNEKNLAFNL AGHVNHTIWWKNLSPNGGDKPTGELAAAIADAFGSFDKFRAQFHAAATTVQGSGWAALGWDTLGNKLLIF QVYDHQTNFPLGIVPLLLLDMWEHAFYLQYKNVKVDFAKAFWNVVNWADVQSRYAAATSQTKGLIFG
Related Vaccines(s)	M. tuberculosis DNA vaccine pAK4-sod
References

SodA