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sigF

Gene Name sigF
Sequence Strain (Species/Organism) Mycobacterium tuberculosis CDC1551
NCBI Gene ID 922492
NCBI Protein GI 15842877
Locus Tag MT3385
Genbank Accession AE000516
Protein Accession NP_337914
Taxonomy ID 83331
Gene Starting Position 3663004
Gene Ending Position 3663789
Gene Strand (Orientation) -
Protein Name RNA polymerase sigma factor SigF
Protein pI 6.53
Protein Weight 26809.27
Protein Length 261
Protein Note Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is a general stress response regulator; expressed in stationary phase and under nitrogen depletion and cold shock
DNA Sequence
>gi|50953765:3663004-3663789 Mycobacterium tuberculosis CDC1551 chromosome, complete genome
GCTACTCCAACTGATCCCGTAGCCGTGCCAATGACTTGGCCAGCAGCCGCGACACGTGCATCTGTGAGAT
ACCGACGCGCTCGGCGATCTGCGTTTGGGTCATCGAGTCGAAGAACCTGAGCACCAAGACCGTTCGTTCC
CGCTCGGGCAACGCCTCGAGCAACGGACGAAGCACCTCCCGATTCTCGATCTGGTCAAGACCCGCATCCA
CGTCGCCCAGGGTGTCTGTGATTGCGCGGGCATCGTCGTCGCTGCCGCCACCGCTGTCGATGGACAAGGT
GTGGTAGGAACTACCCGCCAGCAAACCTTCGATAACCTCAGCGCGGTCCATCCCGAGCTCCGCGGCGAGC
TCCGATGCCGACGGCGCCCGCCCGAGCCGCTGCGACAAATCGGCGGTGGCGGTACCTAGCCGCAGATGCA
GTTCCTTGAGACGCCGGGGAACCTTGACCGACCAGCTGTTGTCGCGGAAGTGTCGTCGGACCTCGCCCAT
GATGGTAGGAACCGCGAAGGAGACGAAGTCCGACCCGGTCTTCACGTCGAAGCGAACCGCGGCGTTGACC
AGCCCGACCCGCGCGACCTGAATAAGGTCGTCACGCGGTTCGCCGCGACCCTCGAACCGCCGCGCGATGT
GATCGGCCAGCGGCAAGCACCGCTGAACGATCTTGTCCCGGTGCCGCTGGAATTCCGGTGAGCCGGCAGG
CAAACCAACCAGCTCGCGAAACATCTCCGGAACGTCGGCGTATTCGTTAGCTCGCGATGCAGAACCGCCG
GCAGCGCGCGCCGTCA
Protein Sequence
>gi|15842877|ref|NP_337914.1| RNA polymerase sigma factor SigF [Mycobacterium tuberculosis CDC1551]
MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIVQRCLPLADHIARRFEGRGEPRDDLIQ
VARVGLVNAAVRFDVKTGSDFVSFAVPTIMGEVRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGR
APSASELAAELGMDRAEVIEGLLAGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLL
EALPERERTVLVLRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE
Molecule Role Virmugen
Molecule Role Annotation A sigF mutation is highly attenuated in Mycobacterium tuberculosis and induced protection from challenge in mice(Geiman et al., 2004).
Related Vaccines(s) Mycobacterium tuberculosis DeltasigF mutant vaccine
References