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HSP70 II

Gene Name HSP70 II
Sequence Strain (Species/Organism) Leishmania infantum JPCM5
NCBI Gene ID 5073319
NCBI Protein GI 146101862
Locus Tag LINJ_35_4220
Genbank Accession FR796467
Protein Accession XP_001469224
Taxonomy ID 435258
Chromosome No 35
Gene Starting Position 1642294
Gene Ending Position 1644234
Gene Strand (Orientation) ?
Protein pI 5.06
Protein Weight 65055.03
Protein Length 646
DNA Sequence 
>gi|339899319:1642294-1644234 Leishmania infantum JPCM5 chromosome 35, complete sequence
AATGAATCGACACAACAAGTTCTACGCTGAGGTGGCTGGCGAGTTGGAGGGGGACGACTACTACGGTGAC
GACGACGACTACAACTATGATGAAGAGTACGAGGAGGAGGGGGAGTACGACGAGGCAGCGTACGAGGCCA
CAGCGAGTGCGGCGCCGCCTGAACCGGCGCACATGTCCGAAAGCACCGCTCAGGCCACTGCGTCCGCCGC
TCCGGCCGTGCGCGTTAACCCGTACACAACGATATCGCCGCAGGTGGACGATGACTACGAGCTGCTCGAC
ATGCTGTTGCCGCAGCTGCACGCCTTGTGGAAAGCAAGTGCACCGACGATGCTGCCGCTCTCGGAGGGCG
AGGCGGTCACGGCACTTCGGGCAAGCAACTACGACGTCGAGCCCGCCTTCCTGCAACTCAAAGAAAAGCG
AGACGAGGAGCGCTCCAAGCGCGGCGGCGGCGTCCTGAAGGTCACCGCAGCTGCTGGACCCGCGAACCGG
GCATCCACTTTTCCAGCTGTCGAGTCACCCGAACCCGGCGGCGAGGAGGCGAGCGATAACGAGGGCAACT
CTGCATCGCCGAGCGCGAGTTCTGGCCGCACCACGACCACCTTGAGGGGCTCGAAGGGCACATCGCAGCG
ACGCACGAAGCAGATGCTAGAGATGGAACCGGACAAGGAGAAGCCGGACTGCACGTTTGTGATTGCCGGC
CACGTCGATGCCGGAAAGAGCACCACGCTGGGCCACCTCCTCCTGCTCTTGGGCCGCGTTAGCATCCAGG
ATGTCGAGAGAAACGAAAAAGCAGACCGCACGCACCGCAAGGACTCCTTCAAGTACGCCTGGCTGCTGGA
CCAGTGTGAGGAGGAGCGGCGCCGTGGCGTCACCATCGACTCCGGCTCTTTCTGCTTCGAAACGGAGCAC
CGTCGCGTGCACATCCTCGATGCCCCAGGGCACAAGGACTTTGTGCTCAGCATGATCAGCAGTGCCACCC
AGGCCGATGCTGCCTTGCTCGTCGTGACGGCGGCCACCTCCGAGTTCGAGACGGGGCTGCACCACGGTAC
CAAGTCTCATCTTCTGGTCTTGAAAACGCTCGGCGTCGGGTCCATTGTCGTCGCCGTCAACAAGATGGAC
GCCGTCGCCTATTCACAGGAGCGCTACGACTACGTGGTGCGGGAGCTGCAGCTCCTGCTCAAGCAGACCC
GCATCCCGGAGGAAGCCATCATCGGCTTTTGCCCCATTAGTGGCATGGCAGGCGTCAACATCACTCAGCG
GGGCGCCAAGGAGACGCCTTGGTACCACGATCTCAGCTTGATCGAGATGATTGACAAGTGTCCGTTGGAG
AGTCGCCTGCTGAACAGACCGCTGCGCCTGAGTCTGCAAGACGTGCAGGGCACCACCCTCTACGCCAAGG
TCGAGAGCGGAAGGCTCTTCACAGGGGACACGGTTCATTTCGTGCCGAGCGAGGTGCGGGTCGCTGTCAA
GTCGATTCAGAAGCCCACTGTGGCTGGCCCTGTTCTCGTCGCCTTTGCTGGCGAGATGGTAGAGATCAGC
ACGAACTCGTCCGTGACAGGACTGTACCCGGGCTGTGTGGGCTGCGAGCCGAATTTGTTAATCCACAGTT
CCACCGACTTTGAGGCGCATATCCAGACCTTTCGCACCCTCACCAAGTCCATCCTGCCAGGGGCGAGCTT
CACCATCATTGTGCACGCCCTGACGGTGCGGGTGCATGTTGTCGCACTCATATCTAAGATGGACGGCAAA
ACAGGAAACTGGTCGAAGGGGATGGTGAAGTGTGTGCCGCCGGCCGCACAGGCGATGATGCTCTTCCGTG
CTGAGTCGCCTGTCGCCCTCGAACCGGCGACGGAGTGCCGCGCGCTGGGGCGGTTTGTCCTTCAGCAGGA
TGGCGAAACGGTTGCTGGCGGCCTGGTCACACGCGTTGTGGACAAGCCGTG
Protein Sequence 
>gi|146101862|ref|XP_001469224.1| hsp70 subfamily B suppressor 1 [Leishmania infantum JPCM5]
MNRHNKFYAEVAGELEGDDYYGDDDDYNYDEEYEEEGEYDEAAYEATASAAPPEPAHMSESTAQATASAA
PAVRVNPYTTISPQVDDDYELLDMLLPQLHALWKASAPTMLPLSEGEAVTALRASNYDVEPAFLQLKEKR
DEERSKRGGGVLKVTAAAGPANRASTFPAVESPEPGGEEASDNEGNSASPSASSGRTTTTLRGSKGTSQR
RTKQMLEMEPDKEKPDCTFVIAGHVDAGKSTTLGHLLLLLGRVSIQDVERNEKADRTHRKDSFKYAWLLD
QCEEERRRGVTIDSGSFCFETEHRRVHILDAPGHKDFVLSMISSATQADAALLVVTAATSEFETGLHHGT
KSHLLVLKTLGVGSIVVAVNKMDAVAYSQERYDYVVRELQLLLKQTRIPEEAIIGFCPISGMAGVNITQR
GAKETPWYHDLSLIEMIDKCPLESRLLNRPLRLSLQDVQGTTLYAKVESGRLFTGDTVHFVPSEVRVAVK
SIQKPTVAGPVLVAFAGEMVEISTNSSVTGLYPGCVGCEPNLLIHSSTDFEAHIQTFRTLTKSILPGASF
TIIVHALTVRVHVVALISKMDGKTGNWSKGMVKCVPPAAQAMMLFRAESPVALEPATECRALGRFVLQQD
GETVAGGLVTRVVDKP
Molecule Role Virmugen
Molecule Role Annotation A Leishmania infantum deletion mutant of HSP70-II gene is attenuated and provides protection against Leishmania infection in the L. major-BALB/c infection model. Also, DeltaHSP70-II is a safe live vaccine as immunodeficient SCID mice, and hamsters, infected with mutant parasites did not develp any sign of pathology (Carrion et al., 2011).
Related Vaccines(s) Leishmania infantum HSP70 II mutant vaccine
References