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guaA from S. typhimurium str. LT2
Gene Name	guaA from S. typhimurium str. LT2
Sequence Strain (Species/Organism)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID	1254032
NCBI Protein GI	16765830
Locus Tag	STM2510
Genbank Accession	AE006468
Protein Accession	NP_461445
Taxonomy ID	700720
Gene Starting Position	2622804
Gene Ending Position	2624381
Gene Strand (Orientation)	-
Protein Name	GMP synthase
Protein pI	5.06
Protein Weight	53458.79
Protein Length	525
Protein Note	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
DNA Sequence	>gi\|16763390:2622804-2624381 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome CTTATTCCCACTCAATGGTAGCCGGCGGTTTACCGCTGATGTCATACACCACACGGGAAATCCCGTTGAC TTCATTGATGATGCGGTTGGAAACGCGACCGAGGAAGTCATACGGCAGGTGCGCCCAGTGTGCGGTCATA AAGTCGATGGTTTCGACGGCACGCAGAGAGACAACCCAGTCATACTTACGACCATCGCCCATAACGCCAA CGGAACGAACCGGCAGGAAGACGGTAAACGCCTGACTGACTTTGTCGTACAGATCCGCTTTGCGCAGCTC TTCAATGAAGATAGCGTCAGCACGGCGCAGCAGGTCGCAGTACTCTTTCTTCACTTCACCCAGAACACGA ACGCCGAGGCCCGGCCCCGGGAACGGATGGCGATACAGCATGTCATACGGCAGGCCCAGCTCCAGACCAA TCTTACGCACTTCGTCTTTGAACAGCTCTTTCAGCGGTTCAACCAGCCCCATCTTCATCTCTTTCGGCAA GCCGCCGACATTGTGGTGAGATTTGATGACGTGCGCTTTACCGGTTGCAGACGCCGCAGATTCGATAACG TCAGGGTAAATGGTGCCTTGCGCCAGCCACTTCACGTCTTCCAGTTTGAGCGCTTCTTCGTCGAACACTT CTACAAAAACACGACCGATGATCTTACGCTTGGCTTCCGGATCGTTCTCGCCAGCCAGCGCGGACAGGAA GCGCTCTTCTGCCGGTACGTGAACGATATTCAGGCCAAAATGGTCGCCAAACATGTCCATCACCTGCTCG GCTTCGTTGAGACGCAGCAGGCCGTTGTCGACGAATACACAGGTCAGATTTTTACCGATCGCGCGGTGCA GCAGCATTGCGGTGACGGAAGAATCCACGCCACCAGAGAGGCCGAGGATCACTTTGTCGTCGCCCACCTG CTCGCGAATGCGCGCCACGGCGTCGTCGATGATCTTCGCCGGCGTCCACAACGCTTCACACTGGCAGATA TCGCGTACAAAACGCTCCAGCATGCGCATACCCTGGCGGGTGTGAGTCACTTCCGGGTGGAACTGTACAC CGTAGAAGCGTTTTTCTTCGTTGGCCATAATGGCGAACGGGCAGCTCTCGGTGCTGGCGACGGTCACGAA GTCGGACGGAATCGCCGTCACTTTATCGCCGTGGCTCATCCACACGTCCAGCAGCGGTTTGCCGTCTGCG GTCAGGGAATCTTCAATACCGCGAACCAGCGCGCTGTCGGTCAACACTTCGACCTGCGCATAACCAAATT CACGCTCATTAGAACCTTCTACATGACCGCCAAGCTGCATCGCCATGGTCTGCATACCATAGCAAACGCC AAATACCGGCACGCCTGCTTCAAAGACATACTGCAGCGCGCGCGGGCTGTTTTCTTCGGTGGTGCTTTCC GGGCCGCCGGAAAGAATAATGCCGCTTGGGTTGAAGTCACGAATTTGTGCTTCTGTCACATCCCACGCCC ACAGTTCACAGTAAACACCCAGCTCACGCACGCGGCGCGCAACCAGTTGAGTGTACTGAGAACCGAAGTC CAGAATGAGGATGCGATGCTTATGAATGTTTTCCGTCA
Protein Sequence	>gi\|16765830\|ref\|NP_461445.1\| GMP synthase [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIRDFNPSGIILSGGPESTTEENSPR ALQYVFEAGVPVFGVCYGMQTMAMQLGGHVEGSNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVW MSHGDKVTAIPSDFVTVASTESCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTP AKIIDDAVARIREQVGDDKVILGLSGGVDSSVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDH FGLNIVHVPAEERFLSALAGENDPEAKRKIIGRVFVEVFDEEALKLEDVKWLAQGTIYPDVIESAASATG KAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYRHPFPGPGLGVRVLGEVKKEY CDLLRRADAIFIEELRKADLYDKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFMTAHWAHLPY DFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE
Molecule Role	Virmugen
Molecule Role Annotation	A guaBA and clpP mutant (CVD 1921) of Salmonella Typhimurium is attenuated in mice after oral immunization. The mutant was also protective, rendering a vaccine efficacy of 86% in mice against challenge with wild type Salmonella Typhimurium (Tennant et al., 2011).
Related Vaccines(s)	Salmonella Typhimurium guaBA/clpP mutant vaccine , Salmonella Typhimurium guaBA/clpP/fliD mutant vaccine
References

guaA from S. typhimurium str. LT2