VIOLIN: Vaccine Investigation and Online Information Network

Pal
Gene Name	Pal
Sequence Strain (Species/Organism)	Haemophilus influenzae 86-028NP
VO ID	VO_0010915
NCBI Gene ID	3429820
NCBI Protein GI	68248984
Locus Tag	NTHI0501
Genbank Accession	CP000057
Protein Accession	YP_248096
Taxonomy ID	281310
Gene Starting Position	470966
Gene Ending Position	471427
Gene Strand (Orientation)	-
Protein Name	outer membrane protein P6
Protein pI	6.52
Protein Weight	14818.12
Protein Length	153
Protein Note	Similar to: HI0381, PAL_HAEIN
DNA Sequence	>NC_007146.2:470966-471427 Haemophilus influenzae 86-028NP, complete genome ATTAGTACGCTAACACTGCACGACGGTTTTTAGAATATGCAGCTTCATCATGACCTAATACTGCAGGTTT TTCTTCACCGTAAGATACTGTGCCTAATTTACCAGCATCAACACCTTTACCAGCTAAATAACCTTTAACT GCATCTGCACGACGTTGGCCTAATGCGATGTTGTATTCTGGTGTACCACGTTCATCAGTGTTACCTTCTA CTAATACTTTAGCAGCTGGCGTTGCATTTAAATATGCAGCGTGCGCATCTAAGATTTGAACGTATTCACC AGTAATGTCATATTTATCAAAACCGAAATAAACGGTATTGTAACGTTGTTGAAGATCAGCAACAGAGTAA CCGCCAAAAGTTTGAGCAGCACCATTGCCTGCAGCATCGTTGTTAGATGAACTACAAGCTGCTAATGCAG CTACAGAACCTGCAACTAATAATGATTTAACAAATTTGTTCA
Protein Sequence	>YP_248096.1 outer membrane protein P6 [Haemophilus influenzae 86-028NP] MNKFVKSLLVAGSVAALAACSSSNNDAAGNGAAQTFGGYSVADLQQRYNTVYFGFDKYDITGEYVQILDA HAAYLNATPAAKVLVEGNTDERGTPEYNIALGQRRADAVKGYLAGKGVDAGKLGTVSYGEEKPAVLGHDE AAYSKNRRAVLAY
Molecule Role	Protective antigen
Molecule Role Annotation	Recombinant P6 (pal) was capable of eliciting a protective antibody response against live H. influenzae type b challenge in a modified infant rat model of bacteremia (Yang et al., 1997). These data demonstrate that active immunization with P6 results in the production of NTHi-specific bactericidal antibody in the chinchilla and also affords a reduction in the incidence of NTHi-induced OM (DeMaria et al., 1996).
Related Vaccines(s)	Non-typeable H. influenzae rLP4/rLP6 and Moraxella catarrhalis UspA2 protein vaccine , recombinant nontypeable H. influenzae protein P6 with AdDP
References

Pal