VIOLIN: Vaccine Investigation and Online Information Network

clpP from S. typhimurium str. LT2
Gene Name	clpP from S. typhimurium str. LT2
Sequence Strain (Species/Organism)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
NCBI Gene ID	1251968
NCBI Protein GI	16763829
Locus Tag	STM0448
Genbank Accession	AE006468
Protein Accession	NP_459444
Taxonomy ID	700720
Gene Starting Position	503209
Gene Ending Position	503832
Gene Strand (Orientation)	+
Protein Name	ATP-dependent Clp protease proteolytic subunit
Protein pI	5.88
Protein Weight	22084.77
Protein Length	207
Protein Note	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
DNA Sequence	>gi\|16763390:503209-503832 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome AATGTCATACAGCGGAGAACGAGATAATTTGGCCCCTCATATGGCGCTGGTGCCGATGGTCATTGAACAG ACCTCACGCGGTGAGCGCTCTTTTGATATCTATTCTCGTCTACTTAAGGAACGCGTCATATTTCTGACCG GCCAGGTCGAAGACCATATGGCTAACCTGATCGTGGCGCAGATGCTGTTCCTGGAAGCGGAAAACCCGGA AAAAGATATCTATCTGTACATTAATTCTCCTGGCGGCGTAATTACTGCGGGGATGTCCATCTATGACACC ATGCAGTTTATTAAGCCAGACGTCAGCACCATTTGTATGGGACAGGCGGCCTCTATGGGGGCGTTTCTGC TGACTGCCGGGGCGAAAGGCAAACGTTTCTGCTTGCCGAACTCTCGCGTCATGATCCACCAGCCGCTGGG CGGCTACCAGGGCCAGGCGACGGATATTGAAATTCACGCCCGCGAAATTTTGAAAGTAAAAGGGCGCATG AATGAACTTATGGCGCATCATACGGGTCAATCTCTTGAGCAGATTGAACGTGATACTGAGCGCGATCGCT TCCTCTCCGCGCCTGAAGCGGTAGAGTACGGTTTGGTTGACTCAATTTTGACCCATCGTAATTG
Protein Sequence	>gi\|16763829\|ref\|NP_459444.1\| ATP-dependent Clp protease proteolytic subunit [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2] MSYSGERDNLAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPE KDIYLYINSPGGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLG GYQGQATDIEIHAREILKVKGRMNELMAHHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN
Molecule Role	Virmugen
Molecule Role Annotation	A mutation in clpP (CS2007) causes hyperflagellation. These hyperflagellated bacteria are attenuated in mice, and an LD50 for CS2007 could not be determined because mice did not die after inoculation with the highest dose. CS2007 also elicited protection in mice from challenge with wild type S. typhimurium (Matsui et al., 2003).
Related Vaccines(s)	Salmonella Typhimurium clpP mutant vaccine , Salmonella Typhimurium guaBA/clpP mutant vaccine , Salmonella Typhimurium guaBA/clpP/fliD mutant vaccine
References

clpP from S. typhimurium str. LT2