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E7 Type 16

General Information
Protegen ID 509
Sequence Strain (Species/Organism) Human papillomavirus type 16
VO ID VO_0011105
Taxonomy ID 333760
Molecule Role Protective antigen
Molecule Role Annotation Researchers combined the HPV16 E7 peptide(38-61) with a murine IgG heavy chain constant region to construct a chimeric protein compound. The chimeric vaccine candidate was able to effectively protect mice against the challenge of HPV16-positive tumor cells, and to eradicate HPV16-expressing tumors in mice (Qin et al., 2005).
Related Vaccines(s) ADXS11-001 , Human papillomavirus DNA vaccine CRT/E7 DNA , Human papillomavirus DNA vaccine E7IR , Human papillomavirus DNA vaccine E7SH DNA , Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2 , Human papillomavirus DNA vaccine Pe7(pcDNA3-Sig/sE7/LAMP) encoding E7 , Human papillomavirus E7 protein vaccine , LM1-2-E7 , MEDI0457
References
Qin et al., 2005: Qin Y, Wang XH, Cui HL, Cheung YK, Hu MH, Zhu SG, Xie Y. Human papillomavirus type 16 E7 peptide(38-61) linked with an immunoglobulin G fragment provides protective immunity in mice. Gynecologic oncology. 2005; 96(2); 475-483. [PubMed: 15661238].
Gene Information
Gene Name E7 Type 16
NCBI Gene ID 1489079
Genbank Accession AB663783
Locus Tag HpV16gp2
Gene Starting Position 7603
Gene Ending Position 7899
DNA Sequence 
>NC_001526.4:7603-7899 Human papillomavirus type 16, complete genome
CATGCATGGAGATACACCTACATTGCATGAATATATGTTAGATTTGCAACCAGAGACAACTGATCTCTAC
TGTTATGAGCAATTAAATGACAGCTCAGAGGAGGAGGATGAAATAGATGGTCCAGCTGGACAAGCAGAAC
CGGACAGAGCCCATTACAATATTGTAACCTTTTGTTGCAAGTGTGACTCTACGCTTCGGTTGTGCGTACA
AAGCACACACGTAGACATTCGTACTTTGGAAGACCTGTTAATGGGCACACTAGGAATTGTGTGCCCCATC
TGTTCTCAGAAACCATA
Protein Information
Protein Name transforming protein E7
NCBI Protein GI 9627105
Protein Accession NP_041326
Protein pI 3.97
Protein Weight 10624.95
Protein Length 98
Protein Note E7 ORF from 544 to 858; putative
Protein Sequence 
>NP_041326.1 transforming protein E7 [Human papillomavirus type 16]
MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQ
STHVDIRTLEDLLMGTLGIVCPICSQKP
Epitope Information
IEDB Linear Epitope