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T. cruzi DNA prime/rTc80 + ODN-CpG boost vaccine |
| Vaccine Information |
- Vaccine Name: T. cruzi DNA prime/rTc80 + ODN-CpG boost vaccine
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Mouse
- Antigen: Tc80 (Bivona et al., 2018)
- Tc80
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Adjuvant:
- Immunization Route: Intramuscular injection (i.m.)
- Description: T. cruzi vaccine involving priming with Tc80 DNA delivered by a bacterial vector followed by a boosting with rTc80 + ODN - CpG (Bivona et al., 2018)
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| References |
Bivona et al., 2018: Bivona AE, Sánchez Alberti A, Matos MN, Cerny N, Cardoso AC, Morales C, González G, Cazorla SI, Malchiodi EL. Trypanosoma cruzi 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine. PLoS neglected tropical diseases. 2018; 12(3); e0006384. [PubMed: 29601585].
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T. cruzi vaccine encoding recombinant enolase from H8 strain |
| Vaccine Information |
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| References |
Arce-Fonseca et al., 2018: Arce-Fonseca M, González-Vázquez MC, Rodríguez-Morales O, Graullera-Rivera V, Aranda-Fraustro A, Reyes PA, Carabarin-Lima A, Rosales-Encina JL. Recombinant Enolase of Trypanosoma cruzi as a Novel Vaccine Candidate against Chagas Disease in a Mouse Model of Acute Infection. Journal of immunology research. 2018; 2018; 8964085. [PubMed: 29854848].
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T. cruzi vaccine using attenuated Salmonella expressing T. cruzi Cruzipain |
| Vaccine Information |
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VVr expressing L. infantum P36/LACK |
| Vaccine Information |
- Vaccine Name: VVr expressing L. infantum P36/LACK
- Vaccine Ontology ID: VO_0004198
- Type: Recombinant vector vaccine
- Status: Research
- Antigen: L. infantum p36/LACK protein
- P36/LACK
gene engineering:
- Type: Recombinant vector construction
- Description: The gene encoding L. infantum p36/LACK protein was expressed by recombinant vaccinia virus, and co-expressed murine IL-12 (Gonzalo et al., 2001).
- Detailed Gene Information: Click Here.
- Adjuvant:
- Vector: Recombinant vaccinia virus (VVr) derived from the wild-type Western Reserve strain (WR) (Gonzalo et al., 2001).
- Immunization Route: Intraperitoneal injection (i.p.)
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| References |
Gonzalo et al., 2001: Gonzalo RM, Rodríguez JR, Rodríguez D, González-Aseguinolaza G, Larraga V, Esteban M. Protective immune response against cutaneous leishmaniasis by prime/booster immunization regimens with vaccinia virus recombinants expressing Leishmania infantum p36/LACK and IL-12 in combination with purified p36. Microbes and infection / Institut Pasteur. 2001; 3(9); 701-711. [PubMed: 11489418].
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