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Adamantylamide Dipeptide Vaccine Adjuvant

Vaxjo ID 34
Vaccine Adjuvant Name Adamantylamide Dipeptide Vaccine Adjuvant
Alternative Names AdDP
Adjuvant VO ID VO_0000559
Description Adamantylamide dipeptide (AdDP) is the desmuramyl analog of MDP. (Zídek et al., 1993)
Stage of Development Research
Components In the search for more potent and less toxic immunomodulators, adamantylamide dipeptide (AdDP) was synthesized by the covalent union of amantadine with the -alanyl- -isoglutamine residue of muramyldipeptide (MDP).(Zídek et al., 1993)
Preparation Adamantylamide dipeptide (AdDP) is a novel compound, which has been obtained by linking the l-alanine-d-isoglutamine residue of MDP to amantadine (Becker et al., 2001).
Dosage AdDP and all other compounds tested for their edemagenic activity were injected in the nape of the neck of mice (n = 4 for each group) at the regular interval of 24 h. The dose of AdDP was 100/Mg/0.5 ml/animal corresponding closely to 4 mg/kg.(Zídek et al., 1993)
Function AdDP promotes a consistent increment in IgG1 antibodies associated with a dominant Th2 response pattern. When administered by the oral route, AdDP was at least as efficient as ODN-CpG as adjuvant (Zídek et al., 1993).
Safety Significant paw swelling occurred as soon as the interval of 3 h (data not shown) following the initial injection of AdDP (as well as MDP). The maximum effect was observed always at the interval of 6 h (values for the 6 h interval were about the same, data not shown) and declined towards 24 h after each injection (Table 1). (Zídek et al., 1993)
Related Vaccine(s)
Becker et al., 2001: Becker PD, Corral RS, Guzmán CA, Grinstein S. Adamantylamide dipeptide as effective immunoadjuvant in rabbits and mice. Vaccine. 2001; 19(32); 4603-4609. [PubMed: 11535307].
Zídek et al., 1993: Zídek Z, Masek K, Franková D, Flegel M. T-cell-dependent immunobiological activity of a desmuramyl analog of muramyl dipeptide, adamantylamide dipeptide (AdDP), and D-isoglutamine. International journal of immunopharmacology. 1993; 15(5); 631-637. [PubMed: 8375945].