Adamantylamide Dipeptide Vaccine Adjuvant |
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Vaxjo ID |
34 |
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Vaccine Adjuvant Name |
Adamantylamide Dipeptide Vaccine Adjuvant |
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Alternative Names |
AdDP |
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Adjuvant VO ID |
VO_0000559
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Description |
Adamantylamide dipeptide (AdDP) is the desmuramyl analog of MDP. (Zídek et al., 1993) |
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Stage of Development |
Research |
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Components |
In the search for more potent and less toxic immunomodulators, adamantylamide dipeptide (AdDP) was synthesized by the covalent union of amantadine with the -alanyl- -isoglutamine residue of muramyldipeptide (MDP).(Zídek et al., 1993) |
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Preparation |
Adamantylamide dipeptide (AdDP) is a novel compound, which has been obtained by linking the l-alanine-d-isoglutamine residue of MDP to amantadine (Becker et al., 2001). |
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Dosage |
AdDP and all other compounds tested for their edemagenic activity were injected in the nape of the neck of mice (n = 4 for each group) at the regular interval of 24 h. The dose of AdDP was 100/Mg/0.5 ml/animal corresponding closely to 4 mg/kg.(Zídek et al., 1993) |
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Function |
AdDP promotes a consistent increment in IgG1 antibodies associated with a dominant Th2 response pattern. When administered by the oral route, AdDP was at least as efficient as ODN-CpG as adjuvant (Zídek et al., 1993). |
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Safety |
Significant paw swelling occurred as soon as the interval of 3 h (data not shown) following the initial injection of AdDP (as well as MDP). The maximum effect was observed always at the interval of 6 h (values for the 6 h interval were about the same, data not shown) and declined towards 24 h after each injection (Table 1). (Zídek et al., 1993) |
| Related Vaccine(s) |
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| References |
Becker et al., 2001: Becker PD, Corral RS, Guzmán CA, Grinstein S. Adamantylamide dipeptide as effective immunoadjuvant in rabbits and mice. Vaccine. 2001; 19(32); 4603-4609. [PubMed: 11535307].
Zídek et al., 1993: Zídek Z, Masek K, Franková D, Flegel M. T-cell-dependent immunobiological activity of a desmuramyl analog of muramyl dipeptide, adamantylamide dipeptide (AdDP), and D-isoglutamine. International journal of immunopharmacology. 1993; 15(5); 631-637. [PubMed: 8375945].
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