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Vaccine Detail

MVA/IL-15/5Mtb vaccine
Vaccine Information
  • Vaccine Name: MVA/IL-15/5Mtb vaccine
  • Vaccine Ontology ID: VO_0004263
  • Type: Recombinant vector vaccine
  • Status: Research
  • Antigen: A recombinant modified vaccinia Ankara (MVA) construct (MVA/IL-15/5Mtb) which overexpresses five Mycobacterium tuberculosis antigens (antigen 85A, antigen 85B, ESAT6, HSP60, and Mtb39) (Kolibab et al., 2010).
  • FbpA (Ag85A) gene engineering:
    • Type: Recombinant vector construction
    • Detailed Gene Information: Click Here.
  • Ag85B from M. tuberculosis H37Rv gene engineering:
    • Type: Recombinant vector construction
    • Detailed Gene Information: Click Here.
  • EsxA (ESAT-6) gene engineering:
    • Type: Recombinant vector construction
    • Detailed Gene Information: Click Here.
  • Adjuvant: IL-15 vaccine adjuvant
  • Immunization Route: subcutaneous injection
References
Kolibab et al., 2010: Kolibab K, Yang A, Derrick SC, Waldmann TA, Perera LP, Morris SL. Highly persistent and effective prime/boost regimens against tuberculosis that use a multivalent modified vaccine virus Ankara-based tuberculosis vaccine with interleukin-15 as a molecular adjuvant. Clinical and vaccine immunology : CVI. 2010; 17(5); 793-801. [PubMed: 20357059].