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Vaccine Detail
MVA/IL-15/5Mtb vaccine |
Vaccine Information |
- Vaccine Name: MVA/IL-15/5Mtb vaccine
- Vaccine Ontology ID: VO_0004263
- Type: Recombinant vector vaccine
- Status: Research
- Antigen: A recombinant modified vaccinia Ankara (MVA) construct (MVA/IL-15/5Mtb) which overexpresses five Mycobacterium tuberculosis antigens (antigen 85A, antigen 85B, ESAT6, HSP60, and Mtb39) (Kolibab et al., 2010).
- FbpA (Ag85A)
gene engineering:
- Type: Recombinant vector construction
- Detailed Gene Information: Click Here.
- Ag85B from M. tuberculosis H37Rv
gene engineering:
- Type: Recombinant vector construction
- Detailed Gene Information: Click Here.
- EsxA (ESAT-6)
gene engineering:
- Type: Recombinant vector construction
- Detailed Gene Information: Click Here.
- Adjuvant:
- Immunization Route: subcutaneous injection
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References |
Kolibab et al., 2010: Kolibab K, Yang A, Derrick SC, Waldmann TA, Perera LP, Morris SL. Highly persistent and effective prime/boost regimens against tuberculosis that use a multivalent modified vaccine virus Ankara-based tuberculosis vaccine with interleukin-15 as a molecular adjuvant. Clinical and vaccine immunology : CVI. 2010; 17(5); 793-801. [PubMed: 20357059].
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