VIOLIN: Vaccine Investigation and Online Information Network

G glycoprotein

General Information

Protegen ID

779

Sequence Strain (Species/Organism)

Hendra henipavirus

VO ID

VO_0011310

Taxonomy ID

63330

Molecule Role

Protective antigen

Molecule Role Annotation

A subunit vaccine formulation containing only recombinant, soluble, attachment glycoprotein G from HeV (sG(HeV)) and CpG adjuvant was evaluated as a potential NiV vaccine in the cat model. Upon oronasal challenge with NiV (50,000TCID50), all vaccinated cats were protected from disease although virus was detected on day 21 post-challenge in one animal (McEachern et al., 2008).

Related Vaccines(s)

Hendra virus G protein vaccine

References

McEachern et al., 2008: McEachern JA, Bingham J, Crameri G, Green DJ, Hancock TJ, Middleton D, Feng YR, Broder CC, Wang LF, Bossart KN. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats. Vaccine. 2008; 26(31); 3842-3852. [PubMed: 18556094].

Gene Information

Gene Name

G glycoprotein

NCBI Gene ID

1446471

Genbank Accession

AF017149

Locus Tag

Hvgp5

Gene Starting Position

8679

Gene Ending Position

11242

DNA Sequence

>NC_001906.3:8679-11242 Hendra virus, complete genome
TAGGACCCAAGTCCTTAACCACATTCTAATGTGAGGGAGAATTAAATGTACATTGAGACTGACAATCTAA
TATACAGAGTGTTTGATCAAGTTAAAACATCAATTGTCAGGAATTCATTGATAAACCAACTTGTTAGTTA
GAATTAAGAAAATATAAGAGCTAATACTCGCAAGTCATTTGCTTCTTCAAGAGCCTGTCTCAACTATCAA
GTGAATACATGATCTAAAACTAGTATGATGGCTGATTCCAAATTGGTAAGCCTGAACAATAATCTATCTG
GTAAAATCAAGGATCAAGGTAAAGTTATCAAGAATTATTACGGCACAATGGACATCAAGAAAATTAACGA
TGGGTTATTAGATAGTAAGATACTTGGGGCGTTTAACACAGTGATAGCTTTGTTGGGATCAATCATCATC
ATTGTGATGAATATCATGATAATTCAAAATTACACCAGAACGACTGATAATCAGGCACTAATCAAAGAGT
CACTCCAGAGTGTACAGCAACAAATCAAAGCTTTAACAGACAAAATCGGGACAGAGATAGGCCCCAAAGT
CTCACTAATTGACACATCCAGCACCATCACAATTCCTGCTAACATAGGGTTACTGGGATCCAAGATAAGT
CAGTCTACCAGCAGTATTAATGAGAATGTTAACGATAAATGCAAATTTACTCTTCCTCCTTTAAAGATTC
ATGAGTGTAATATCTCTTGTCCGAATCCTTTGCCTTTCAGAGAATACCGACCAATCTCACAAGGGGTGAG
TGATCTTGTAGGACTGCCGAACCAGATCTGTCTACAGAAGACAACATCAACAATCTTAAAGCCCAGGCTG
ATATCCTATACTCTACCAATTAATACCAGAGAAGGGGTTTGCATCACTGACCCACTTTTGGCTGTTGATA
ATGGCTTCTTCGCCTATAGCCATCTTGAAAAGATCGGATCATGTACTAGAGGAATTGCAAAACAAAGGAT
AATAGGGGTGGGTGAGGTATTGGATAGGGGTGATAAGGTGCCATCAATGTTTATGACCAATGTTTGGACA
CCACCCAATCCAAGCACCATCCATCATTGCAGCTCAACTTACCATGAAGATTTTTATTACACATTGTGCG
CAGTGTCCCATGTGGGAGATCCTATCCTTAACAGTACTTCCTGGACAGAGTCACTGTCTCTGATTCGTCT
TGCTGTAAGACCAAAAAGTGATAGTGGAGACTACAATCAGAAATACATCGCTATAACTAAAGTTGAAAGA
GGGAAGTACGATAAGGTGATGCCTTACGGTCCATCAGGTATCAAGCAAGGGGATACATTGTACTTTCCGG
CCGTCGGTTTTTTGCCAAGGACCGAATTTCAATATAATGACTCTAATTGTCCCATAATTCATTGCAAGTA
CAGCAAAGCAGAAAACTGTAGGCTTTCAATGGGTGTCAACTCCAAAAGTCATTATATTTTGAGATCAGGA
CTATTGAAGTATAATCTATCTCTTGGAGGAGACATCATACTCCAATTTATCGAGATTGCTGACAATAGAT
TGACCATCGGTTCTCCTAGTAAGATATACAATTCCCTAGGTCAACCCGTTTTCTACCAGGCATCATATTC
TTGGGATACGATGATTAAATTAGGCGATGTTGATACCGTTGACCCTCTAAGAGTACAGTGGAGAAATAAC
AGTGTGATTTCTAGACCTGGACAGTCACAGTGTCCTCGATTTAATGTCTGTCCCGAGGTATGCTGGGAAG
GGACATATAATGATGCTTTTCTAATAGACCGGCTAAACTGGGTTAGTGCTGGTGTTTATTTAAACAGTAA
CCAAACTGCAGAGAACCCTGTGTTTGCCGTATTCAAGGATAACGAGATCCTTTACCAAGTTCCACTGGCT
GAAGATGACACAAATGCACAAAAAACCATCACAGATTGCTTCTTGCTGGAGAATGTCATATGGTGTATAT
CACTAGTAGAAATATACGATACAGGAGACAGTGTGATAAGGCCAAAACTATTTGCAGTCAAGATACCTGC
CCAATGTTCAGAGAGTTGATTGACCAAAAGAGCAATAAATATTATATTATAATTATATCAGTCAAATTGT
AAACATCCTTCTTATAATATACTCAAAAAATTAAAAATTCCCCCAAGAAAATACTAAATGTAATCAAACT
CAATAAACCCTGAAATATTGATAGTTTACAGAGATCATATGACTCTTTGTATAATTCTTTATAGAACTCC
TAAATATCAAAGAGCGATAAACTTGCTACCCTGTACACTTAAAGCAGATACTGTGATTAACTCTGTAAGT
TTATCAGATAATCCTATTAGTGACATACTGAGGGTTATTCTTGTATAATTCTTCTGAAGATGTGATTACA
GATAATCTTTCAATCTAGTCAAGTAAGCCTGATTTCCTAATTATAATCTCCCTCTTAGGAGAAGGAGAAC
GTATCAATGTTCACTATATACTAAGTCTTTTATTTTAAATTTTTCTTATTGTCTTCAGATGAGCCTTATT
ACTTCATCTCATCAGATTATAAATTTTCTAATAAATTAAGAAAA

Protein Information

Protein Name

glycoprotein

NCBI Protein GI

29468607

Protein Accession

NP_047112

3D structure: PDB ID

2X9M

Protein pI

7.51

Protein Weight

63419.1

Protein Length

604

Protein Sequence

>NP_047112.2 glycoprotein [Hendra henipavirus]
MMADSKLVSLNNNLSGKIKDQGKVIKNYYGTMDIKKINDGLLDSKILGAFNTVIALLGSIIIIVMNIMII
QNYTRTTDNQALIKESLQSVQQQIKALTDKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTSSINE
NVNDKCKFTLPPLKIHECNISCPNPLPFREYRPISQGVSDLVGLPNQICLQKTTSTILKPRLISYTLPIN
TREGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFMTNVWTPPNPSTIH
HCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKSDSGDYNQKYIAITKVERGKYDKVMP
YGPSGIKQGDTLYFPAVGFLPRTEFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSL
GGDIILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQ
SQCPRFNVCPEVCWEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQK
TITDCFLLENVIWCISLVEIYDTGDSVIRPKLFAVKIPAQCSES

Epitope Information

IEDB Linear Epitope