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SfbI

General Information
Protegen ID 851
Sequence Strain (Species/Organism) Streptococcus pyogenes DSM 2071
VO ID VO_0012394
Taxonomy ID 1314
Other Database IDs CDD:311998
CDD:331285
CDD:308566
Molecule Role Protective antigen
Molecule Role Annotation Intranasal immunization of mice with either SfbI alone or coupled to cholera toxin B subunit (CTB) triggered efficient SfbI-specific humoral (mainly IgG) and lung mucosal (14% of total IgA) responses. SfbI-vaccinated animals showed 80% and 90% protection against homologous and heterologous challenge, respectively (Guzmán et al., 1999).
Peptides incorporated in the Lipid-Core Peptide (LCP) vaccine delivery system derived from the important streptococcal virulence factors M protein and the fibronectin-binding protein SfbI. The present work clearly demonstrates the potential of these synthetic dual antigen multi-epitope mucosal GAS prophylactic vaccines as an approach to deliver vaccine antigens and adjuvants across mucosal membranes resulting in the stimulation of protective immune responses.(Schulze et al., 2017)
Related Vaccines(s) S. pyogenes SfbI Protein Vaccine
References
Guzmán et al., 1999: Guzmán CA, Talay SR, Molinari G, Medina E, Chhatwal GS. Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI. The Journal of infectious diseases. 1999; 179(4); 901-906. [PubMed: 10068585].
Schulze et al., 2017: Schulze K, Ebensen T, Chandrudu S, Skwarczynski M, Toth I, Olive C, Guzman CA. Bivalent mucosal peptide vaccines administered using the LCP carrier system stimulate protective immune responses against Streptococcus pyogenes infection. Nanomedicine : nanotechnology, biology, and medicine. 2017; 13(8); 2463-2474. [PubMed: 28887213].
Gene Information
Gene Name SfbI
NCBI Nucleotide GI 511149
DNA Sequence 
>gi|511149|emb|X67947.1| S.pyogenes Sfb gene for fibronectin-binding protein (partial)
TAAAGCAATATTTTCTCAAAAAATCATTTTCAAAAACATTAATTTGGTGAAAAATATAATCAAAAAATTG
TCTTTCTTGACAATAACGTGGTAAGCTCATATATGTTTGTGAGAGGAGAGAAAATGAATAACAAAATGTT
TTTGAACAAAGAAGCCGGTTTTTTGGCACACACAAAAAGAAAAAGGCGATTTGCTGTCACTTTAGTGGGA
GTCTTTTTTATGCTTTTGGCATCCGCGGGTGCTATCGGTTTTGGTCAAGTAGCCTATGCTGCCGATGAGA
AGACTGTGCCTCATAGAGTTAGTCAAAATCCTGAGTTTCCCTGGTATGGTTATGATTTCTACAAAGGACC
TTACACAAGATATCATAATTTACAGCTAAATCTCAACGGAAGTAAAACATATCAGGCTTATTGTTTTAAT
TTAAAGAGATTTGAACCTAAGAAAGAAGGTAGTTATTTTCCGAATTGGTATAAGAGGTGGGATGGTAGTG
AAGAGACATTTGTAAAATATGCTGATAACCCCAGAAAAGATAATGAAAGTTCCAGAGTTATAGATGTAGA
ATTAGAAAAAAATATATTAAGAGTGCTATATAATGGATATCCGAATAACGGTAATGGAATCATGGAGGGT
TTAGAACCATTAAATGCTATCTTAGTAACTCAAAATGCTGTTTGGTACTATTCTGATAATTCATCTATTT
TTAATACTGATAACTTCTTTACGACTGAAGCTAAAGATCTTAATATAAAACCTGAGCAATTATCATTAAT
GCGTGTTGCATTAAAGAAATTGATAGATCCTAAGTTATCTGAAGAATCATTGAAACCTGTGCCATCTACT
TTTAGACTGAATATTTTCGAATCTCAGGATAAGCTATATCAAAATCTTCTAAGTGCTGAGTTTGTACCAG
AAAATCCCCCTAAACCTGGTGAAACCCCTGAACATGGACCCAAAACTCCCGAGTTGGATGGCACTCCAAT
TCCCGAAGGCCCACAACGTCCAAATGAGAGTTTAGAACCTACGCTTCCACCAGTGATGCTAGACGGACAA
GAAGTCCCCGAAGTTCCAAGTGAGAGCTTAGAACCTGCGCTTCCCCCATTGATGCCAGAGCTAGATGGCC
AAGAAGTCCCAGAAGTTCCAAGCGAGAGCTTAGAACCTGCGCTTCCCCCATTGATGCCAGAGTTAGATGG
TCAAGAAGTCCCTGAAAAACCTAGTGTTGACTTACCTATTGAAGATCCTCGTTATGAGTTTAACAATAAA
GACCAATCACCTCTAGCGGGTGAGTCTGGTGAGACGGAGTATATTACCGAAGTTTATGGAAATCAACAGA
ACCCTGTTGATATTGATAAAAAACTTCCGAATGAAACAGGTTTTTCAGGAAATATGGTTGAGACAGAAGA
TACGAAAGAGCCAGGAGTGTTGATGGGAGGTCAAAGTGAGTCTGTTGAATTTACTAAAGACACTCAAACA
GGCATGAGTGGTCAAACAACTCCTCAGGTTGAGACAGAAGACACGAAAGAGCCAGGAGTGCTGATGGGAG
GTCAAAGTGAGTCTGTTGAATTTACCAAAGATACTCAAACAGGCATGAGTGGTCAAACAGCTTCTCAGGT
TGAGACAGAAGATACGAAAGAGCCAGGAGTGCTGATGGGAGGCCAAAGTGAGTCTGTTGAATTTACTAAA
GACACTCAAACAGGCATGAGTGGTCAAACAACTCCTCAGGTTGAGACAGAAGACACGAAAGAGCCAGGAG
TATTGATGGGAGGTCAAAGTGAATCTGTTGAATTTACTAAAGACACTCAAACAGGCATGAGCGGTTTCAG
TGAAACAGTGACCATTGTTGAAGATACCCGTCCGAAGTTAGTGTTCCATTTTGACAATAATGAGCCCAAA
GTGGAAGAGAATCGGGAAAAGCCTACAAAAAATATAACACCTATCCTTCCTGCAACAGGAGATATTGAGA
ATGTTTTGGCCTTTCTTGGAATCCTTATTTTGTCAGTACTTCCTATTTTTAGTCTTTTAAAAAAACAAAC
AAAACAATAAAGTCTGATCGTAAAAGTGTTCCATAAGAAATAATGCGCAAATATGCTGAATAGTGGATAA
CTGCTACAGTCAAGACAAGTGTTAATTCAAAAGGTACTACTTATACATCTGATAATAATAAGGTGACAGA
TAATTCAGAGCAAGTAGGATGGCTAAAAAATGGTGTATTCTATGTATAATAGACTACATAGAAATCAAGT
TATTGTTAAACGTCGTAAAGCTT
Protein Information
Protein Name fibronectin-binding protein SfbI
NCBI Protein GI WP_014407228
Protein Accession CAA48133.1
Protein pI 4.15
Protein Weight 64222.46
Protein Length 694
Protein Note Thioester domain; pfam08341
Protein Sequence 
>WP_014407228.1 fibronectin-binding protein SfbI [Streptococcus pyogenes]
MNNKIFLNKEAGFLAHTKRKRRFAVTLVGVFFMLLACAGAIGFGQVAYAADERTVPNHSSTNPEFPWYGY
DSYRGIFARYHNLKVNLKGSKEYQAYCFNLTKYFPRPTYSTTNNFYKKIDGSGSAFKSYAANPRVLDENL
DKLEKNILNVIYNGYKSNANGFMNGIEDLNAILVTQNAIWYYSDSAPLNDVNKMWEREVRNGEISESQVT
LMREALKKLIDPNLEATAVNKIPSGYRLNIFKSENEDYQNLLSAEYVPDDPPKPGDTSEHNPKTPELDGS
PIPEDPKHPDDNLEPTLPPVMLDGEEVPEVPSESLEPALPPLMPELDGEEVPEVPSESLEPALPPLMPEL
DGEEVPEVPSESLEPALPSLMPELDGEEVPEVPSESLEPAFPPLMPELDGQEVPEKPSVDLPIEVPRYEF
NNKDQSPLAGESGETEYITEVYGNQQNPVDIDKKLPNETGFSGNMVETEDTKEPEVLMGGQSESVEFTKD
TQTGMSGQTTPQVETEDTKEPGVLMGGQSESVEFTKDTQTGMSGFSETVTIVEDTRPKLVFHFDNNEPKV
EENREKPTKNIAPILPATGDIGNVLAFLGILILSVLSIFSLLKNKQNNKV
Epitope Information
IEDB Linear Epitope