VIOLIN: Vaccine Investigation and Online Information Network

fnbA

General Information

Protegen ID

849

Sequence Strain (Species/Organism)

Staphylococcus aureus subsp. aureus NCTC 8325

VO ID

VO_0012392

Taxonomy ID

93061

Other Database IDs

CDD:309682
CDD:331378
CDD:313621
CDD:308566
CDD:307064

Molecule Role

Protective antigen

Molecule Role Annotation

Mice were immunized with fusion proteins encompassing the fibronectin-binding domain of a staphylococcal fibronectin-binding protein (FnBP-A). Vaccination of mice with recombinant FnBP resulted in significant protection against challenge with S. aureus (Mamo et al., 1994).

Related Vaccines(s)

S. aureus DNA vaccine encoding Efb, FnbpA, ClfA, Cna , S. aureus FnbA Protein Vaccine

References

Mamo et al., 1994: Mamo W, Jonsson P, Flock JI, Lindberg M, MÃ¼ller HP, WadstrÃ¶m T, Nelson L. Vaccination against Staphylococcus aureus mastitis: immunological response of mice vaccinated with fibronectin-binding protein (FnBP-A) to challenge with S. aureus. Vaccine. 1994; 12(11); 988-992. [PubMed: 7975852].

Gene Information

Gene Name

fnbA

Protein Information

Protein Name

Fibronectin-binding protein A

NCBI Protein GI

120457

Protein pI

4.36

Protein Weight

105986.3

Protein Length

1133

Protein Note

FnbpA

Protein Sequence

>sp|P14738.1|FNBA_STAA8 RecName: Full=Fibronectin-binding protein A; Short=FnbpA; Flags: Precursor
MKNNLRYGIRKHKLGAASVFLGTMIVVGMGQDKEAAASEQKTTTVEENGNSATDNKTSETQTTATNVNHI
EETQSYNATVTEQPSNATQVTTEEAPKAVQAPQTAQPANIETVKEEVVKEEAKPQVKETTQSQDNSGDQR
QVDLTPKKATQNQVAETQVEVAQPRTASESKPRVTRSADVAEAKEASNAKVETGTDVTSKVTVEIGSIEG
HNNTNKVEPHAGQRAVLKYKLKFENGLHQGDYFDFTLSNNVNTHGVSTARKVPEIKNGSVVMATGEVLEG
GKIRYTFTNDIEDKVDVTAELEINLFIDPKTVQTNGNQTITSTLNEEQTSKELDVKYKDGIGNYYANLNG
SIETFNKANNRFSHVAFIKPNNGKTTSVTVTGTLMKGSNQNGNQPKVRIFEYLGNNEDIAKSVYANTTDT
SKFKEVTSNMSGNLNLQNNGSYSLNIENLDKTYVVHYDGEYLNGTDEVDFRTQMVGHPEQLYKYYYDRGY
TLTWDNGLVLYSNKANGNEKNGPIIQNNKFEYKEDTIKETLTGQYDKNLVTTVEEEYDSSTLDIDYHTAI
DGGGGYVDGYIETIEETDSSAIDIDYHTAVDSEAGHVGGYTESSEESNPIDFEESTHENSKHHADVVEYE
EDTNPGGGQVTTESNLVEFDEESTKGIVTGAVSDHTTVEDTKEYTTESNLIELVDELPEEHGQAQGPVEE
ITKNNHHISHSGLGTENGHGNYDVIEEIEENSHVDIKSELGYEGGQNSGNQSFEEDTEEDKPKYEQGGNI
VDIDFDSVPQIHGQNKGNQSFEEDTEKDKPKYEHGGNIIDIDFDSVPHIHGFNKHTEIIEEDTNKDKPSY
QFGGHNSVDFEEDTLPKVSGQNEGQQTIEEDTTPPIVPPTPPTPEVPSEPETPTPPTPEVPSEPETPTPP
TPEVPSEPETPTPPTPEVPAEPGKPVPPAKEEPKKPSKPVEQGKVVTPVIEINEKVKAVAPTKKPQSKKS
ELPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA

Epitope Information

IEDB Linear Epitope