VIOLIN: Vaccine Investigation and Online Information Network

MIC10

General Information

Protegen ID

614

Sequence Strain (Species/Organism)

Neospora caninum

VO ID

VO_0011198

Taxonomy ID

29176

Molecule Role

Protective antigen

Molecule Role Annotation

This study used an immunisation/challenge model of transplacental transmission, based on the Qs mouse with an Nc-Liverpool challenge to investigate the vaccine potential of a number of formulations based on four recombinant proteins of N. caninum. A mixture of MIC10 and p24B produced partial protection against transplacental transmission of N. caninum in this mouse model (Ellis et al., 2008).

Note: MIC10 must be used in conjunction with p24B in order to confer protection against N. caninum.

Related Vaccines(s)

N. caninum MIC10 and p24 protein vaccine

References

Ellis et al., 2008: Ellis J, Miller C, Quinn H, Ryce C, Reichel MP. Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model). Vaccine. 2008; 26(47); 5989-5996. [PubMed: 18789996].

Gene Information

Gene Name

MIC10

NCBI Gene ID

13445423

Protein Information

Protein Name

NcMIC10 precursor

NCBI Protein GI

11141617

Protein pI

9.31

Protein Weight

23276.72

Protein Length

251

Protein Sequence

>AAG32025.1 NcMIC10 precursor [Neospora caninum]
MALSTMNKPGPFRRLLGYGLLLGAVVLEAAFDLSAPAEAVALRRLDQKETVQALVEQHRFSNDYDQEAEY
RRRRQELGSQTPEEIEEAKRKYRKQVLKEQQEDEELKKKTDAVIEELKKTAEERGLRRYPERDEDRTDDQ
QMDFETRQRELRNMDSATKAQLLKQRRKENEERNRVKRNSDDVMAELKQKLAARKKAM

Epitope Information

IEDB Linear Epitope