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ExbB

General Information
Protegen ID 601
Sequence Strain (Species/Organism) Neisseria meningitidis MC58
VO ID VO_0011186
Taxonomy ID 122586
Molecule Role Protective antigen
Molecule Role Annotation A total of 11 meningococcal proteins that are necessary for establishing systemic infection were expressed as recombinant antigens and assessed for their ability to protect mice against live bacterial challenge against N. meningitidis; ExbB, which is required for iron acquisition, elicited protective immunity (Sun et al., 2005).
COG COG0811U, under U: Intracellular trafficking, secretion, and vesicular transport
Related Vaccines(s) N. meningitidis ExbB Protein Vaccine
References
Sun et al., 2005: Sun Y, Li Y, Exley RM, Winterbotham M, Ison C, Smith H, Tang CM. Identification of novel antigens that protect against systemic meningococcal infection. Vaccine. 2005; 23(32); 4136-4141. [PubMed: 15964482].
Gene Information
Gene Name ExbB
NCBI Gene ID 903370
Genbank Accession AE002098
Locus Tag NMB1729
Gene Starting Position 1812128
Gene Ending Position 1812790
DNA Sequence 
>NC_003112.2:1812128-1812790 Neisseria meningitidis MC58 chromosome, complete genome
ATCAGCTATCCTTTTGATTAAGCAGGCGGACGTGCAAATCGTGCGCCATCGCATCCAAATCCTGGGTCAG
TATTTTTGTGCCGCGATTGAGGAAGTTGTATGCCAACACCGCCGGAATCGCCACGAACAAACCCGCCGCC
GTCGCCACCAGTGCCTCGCCAATCGGGCCGGCAACCGCCGCAATACTCATCTGCCCGCTTTGCCCGATAT
TGATCAGGGCGTGGTAAATCCCCCAAACCGTGCCGAACAGCCCGATAAACGGCGCGGTCGCGCCGATGGA
GGCAAGCGCGGTCATCCCGTAATCAAACCGGCGCATAATCTGCGCCATACTGTTGCGGATTTGAATGACC
AAATACTCGTTCAACGGCAAAGCCTGCGCCAGTTCGGACGCTTCGTTTCGGCGGTAGTTGCGGTAAGACT
GCAATGCCTCTTGCGCCAGTTTGGACAAAGGCGCATCGACGGCGCGCACTTTTTCGACCGCGTCGTTCAG
CGACAAAGTATCGCGCATATGCCGTTTGACGGCGGCATTCCCTTTGCGCGCCCGATACAGCTTGATGCAG
CGCAAGACAACCAAACACCACGTTACGATACTCATCAACAGCATCAACACAAACACACCAATCAGGACGG
GATCGCCCGATTCAAACACTAATTTCAAATTCA
Protein Information
Protein Name biopolymer transport protein
NCBI Protein GI 15677575
Protein Accession NP_274732
Protein pI 9.81
Protein Weight 22358.4
Protein Length 220
Protein Note identified by similarity to EGAD:145333; match to protein family HMM PF01618
Protein Sequence 
>NP_274732.1 biopolymer transport protein [Neisseria meningitidis MC58]
MNLKLVFESGDPVLIGVFVLMLLMSIVTWCLVVLRCIKLYRARKGNAAVKRHMRDTLSLNDAVEKVRAVD
APLSKLAQEALQSYRNYRRNEASELAQALPLNEYLVIQIRNSMAQIMRRFDYGMTALASIGATAPFIGLF
GTVWGIYHALINIGQSGQMSIAAVAGPIGEALVATAAGLFVAIPAVLAYNFLNRGTKILTQDLDAMAHDL
HVRLLNQKDS
Epitope Information
IEDB Linear Epitope