VIOLIN: Vaccine Investigation and Online Information Network

lpdA

General Information

Protegen ID

596

Sequence Strain (Species/Organism)

Neisseria meningitidis

VO ID

VO_0011181

Taxonomy ID

487

Other Database IDs

CDD:133458
CDD:304358
CDD:180579
CDD:278498
CDD:280934
GOA:Q51191
HSSP: 1OJT
InterPro: IPR000089
InterPro: IPR000815
InterPro: IPR001327
InterPro: IPR003016
InterPro: IPR004099
InterPro: IPR006258
InterPro: IPR011053
InterPro: IPR012999
InterPro: IPR013027
InterPro: IPR016156
UniProtKB/TrEMBL: Q51191

Molecule Role

Other

Molecule Role Annotation

Sera of the challenge group immunized with CCPS-P64kR showed a three-fold higher bactericidal response than the sera of the group immunized with the plain CCPS and they were able to protect against challenge with Neisseria meningococci in the infant rat protection model (Carmenate et al., 2004).

Related Vaccines(s)

CCPS-P64kR

References

Carmenate et al., 2004: Carmenate T, CanaÃ¡n L, Alvarez A, Delgado M, GonzÃ¡lez S, MenÃ©ndez T, RodÃ©s L, GuillÃ©n G. Effect of conjugation methodology on the immunogenicity and protective efficacy of meningococcal group C polysaccharide-P64k protein conjugates. FEMS immunology and medical microbiology. 2004; 40(3); 193-199. [PubMed: 15039094].

Gene Information

Gene Name

lpdA

Protein Information

Protein Name

outer membrane protein P64k or PM-6

NCBI Protein GI

1017430

Protein pI

4.94

Protein Weight

56755.94

Protein Length

685

Protein Note

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; cd06849

Protein Sequence

>CAA57206.1 outer membrane protein P64k or PM-6, partial [Neisseria meningitidis]
MALVELKVPDIGGHENVDIIAVEVNVGDTIAVDDTLITLETDKATMDIPAEVAGVVKEVKVKVGDKISEG
GLIVVVEAEGAATAPKAEAPATPAQEAPKAAAPAPQAAQFGGSADAEYDVVLGGGPGGYSAAFAAADEGL
KVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEVRHLAANGIKYPEPELDIDMLRAYKNGVVSRLTGG
LAGMAKRRKVDVIQGDGQFLDPHHLEVSLTAGDAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDP
RIIDSSGALALKEVPGKLLIIGAGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQNEYRF
DNIMVNTKTVAVEPKEDGVYVTFEGANAPKEPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEVDK
QMRTNVPHIYAIVDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEVAWVGETELSAKA
SGRKITKANFPWAASGRAIANGCDNGFTKLIFDAETGRIIGGGIVGPNGGDMIGEVCLAIEMGCDAADIG
KTIHPHPTLGESIGMAAEVALGTCTDLPPQKKK

Epitope Information

IEDB Linear Epitope