VIOLIN Logo
VO Banner
Search: for Help
Protegen Home
Introduction
Statistics
News and Updates
Protegen Query
Protegen BLAST
Selected Bacteria
Brucella spp. (26)
B. anthracis (14)
E. coli (40)
M. tuberculosis (26)
N. meningitidis (18)
Selected Viruses
Ebola virus (19)
HIV (41)
Influenza virus (50)
Selected Parasites
Plasmodium (47)
Data Submission
Data Exchange
Data Download
Documentation
FAQs
Disclaimer
Contact Us
UMMS Logo


26S mRNA

General Information
Protegen ID 593
Sequence Strain (Species/Organism) Venezuelan equine encephalitis virus
Taxonomy ID 11036
Molecule Role Protective antigen
Molecule Role Annotation Representative variants from a library in which the E1 gene from VEEV IA/B was held constant and only the E2 genes of the five parent viruses were recombined elicited significantly increased neutralizing antibody titers to VEEV IA/B compared to the parent DNA vaccine and provided improved protection against aerosol VEEV IA/B challenge in BALB/c mice (Dupuy et al., 2009).
Related Vaccines(s) VEE virus DNA vaccine encoding 26S
References
Dupuy et al., 2009: Dupuy LC, Locher CP, Paidhungat M, Richards MJ, Lind CM, Bakken R, Parker MD, Whalen RG, Schmaljohn CS. Directed molecular evolution improves the immunogenicity and protective efficacy of a Venezuelan equine encephalitis virus DNA vaccine. Vaccine. 2009; 27(31); 4152-4160. [PubMed: 19406186].
Gene Information
Gene Name 26S mRNA
NCBI Gene ID 2652924
Genbank Accession AY973944
Locus Tag VEEVgp3
Gene Starting Position 7531
Gene Ending Position 11443
DNA Sequence 
>NC_001449.1:7531-11443 Venezuelan equine encephalitis virus, complete genome
AATGGACTACGACATAGTCTAGTCCGCCAAGATGTTCCCGTTCCAACCAATGTATCCGATGCAGCCAATG
CCCTATCGTAACCCGTTCGCGGCCCCGCGCAGGCCCTGGTTCCCCAGAACCGACCCTTTTCTGGCGATGC
AGGTGCAGGAATTAACCCGCTCGATGGCTAACCTGACGTTCAAGCAACGCCGGGACGCGCCACCTGAGGG
GCCACCTGCTAAGAAACCTAAGAGGGAGGCCCCGCAAAAGCAAAAAGGGGGAGGCCAAGGGAAGAAGAAG
AAGAACCAGGGGAAGAAGAAGGCCAAGACGGGGCCGCCTAATCCGAAGGCACAGAGTGGAAACAAGAAGA
AGCCCAACAAGAAACCAGGCAAGAGACAGCGCATGGTCATGAAATTGGAATCTGACAAGACATTCCCAAT
TATGCTGGAAGGGAAGATTAACGGCTACGCTTGCGTGGTCGGAGGGAAGTTATTCAGGCCGATGCACGTG
GAAGGCAAGATCGACAACGACGTTCTGGCCGCACTTAAGACGAAGAAAGCATCCAAATATGATCTTGAGT
ATGCAGATGTGCCACAGAACATGCGGGCCGATACATTCAAGTACACCCATGAGAAGCCCCAAGGCTATTA
CAGCTGGCATCATGGAGCAGTCCAATATGAAAATGGGCGTTTCACGGTGCCAAAAGGAGTTGGGGCCAAG
GGAGACAGCGGAAGACCCATTCTGGATAATCAGGGACGGGTGGTCGCTATTGTGCTGGGAGGTGTGAATG
AAGGATCTAGGACAGCCCTTTCAGTCGTCATGTGGAACGAGAAGGGAGTAACTGTGAAGTATACTCCGGA
GAACTGCGAGCAATGGTCACTAGTGACCACTATGTGCCTGCTCGCCAATGTGACGTTCCCATGTGCCGAA
CCACCAATTTGCTACGACAGAAAACCAGCAGAGACTTTGGCCATGCTCAGCGTTAACGTTGACAACCCGG
GCTACGATGAGCTGCTGGAAGCAGCTGTTAAGTGCCCCGGAAGAAAAAGGAGATCTACCGAGGAGCTGTT
TAAGGAGTATAAGCTAACGCGCCCTTACATGGCCAGATGCATCAGATGTGCCGTTGGGAGCTGCCATAGT
CCAATAGCAATTGAGGCAGTGAAGAGCGACGGGCACGACGGCTATGTTAGACTTCAGACTTCCTCGCAGT
ATGGCCTGGATTCCTCTGGCAACTTAAAGGGAAGGACTATGCGGTATGATATGCACGGGACCATTGAAGA
GATACCACTACATCAAGTGTCACTCCACACATCTCGCCCGTGTCACATTGTGGATGGGCATGGTTATTTT
CTGCTTGCTAGGTGCCCGGCAGGGGACTCCATCACCATGGAATTTAAGAAAGGTTCAGTCACACACTCCT
GCTCAGTGCCGTATGAAGTGAAATTTAATCCTGTAGGCAGAGAACTCTACACTCATCCACCAGAACACGG
AGCAGAGCAAGCGTGCCAAGTCTACGCGCACGATGCACAGAACAGAGGAGCTTATGTCGAGATGCACCTC
CCGGGCTCAGAAGTGGACAGCAGTTTGATTTCCTTGAGCGGCAGTTCAGTCACCGTGACACCTCCTGTCG
GGACTAGCGCCTTGGTGAAATGCAAGTGCGGCGGCACAAAGATCTCCGAAACCATCAACAAGGCAAAACA
GTTCAGCCAGTGCACAAAGAAGGAGCAGTGCAGAGCATATCGACTGCAGAATGACAAGTGGGTGTATAAT
TCTGACAAACTGCCCAAAGCAGCGGGAGCCACCCTAAAAGGAAAACTACACGTCCCGTTCTTGCTGGCAG
ACGGCAAATGCACCGTGCCTCTAGCACCGGAACCTATGATAACCTTCGGTTTCCGATCAGTGTCACTGAA
ACTGCACCCTAAGAATCCCACATATCTGACCACTCGCCAACTTGCTGATGAGCCTCATTACACGCACGAG
CTCATATCTGAACCAGCTGTTAGGAATTTTACCGTCACTGAAAAGGGGTGGGAGTTTGTATGGGGAAACC
ATCCGCCGAAAAGGTTTTGGGCACAGGAAACAGCACCCGGAAATCCACATGGGCTGCCACATGAGGTGAT
AACTCATTATTACCACAGATACCCTATGTCCACCATCCTGGGTTTGTCAATTTGCGCCGCCATTGTAACC
GTTTCCGTTGCAGCGTCCACCTGGCTGTTTTGCAAATCCAGAGTTTCGTGCCTAACTCCTTACCGGCTAA
CACCTAACGCCAGGATGCCGCTTTGCCTGGCCGTGCTTTGCTGCGCCCGCACTGCCCGGGCCGAGACCAC
CTGGGAGTCCTTGGATCACCTATGGAACAATAACCAACAGATGTTCTGGATTCAATTGCTGATCCCTCTG
GCCGCCTTGATTGTAGTGACTCGCCTGCTCAAGTGCGTGTGCTGTGTAGTGCCTTTTTTAGTCGTGGCCG
GCGCCGCAGGCGCCGGCGCCTACGAGCACGCGACCACGATGCCGAGCCAAGCGGGAATCTCGTATAACAC
CATAGTCAACAGAGCAGGCTACGCGCCACTCCCTATCAGCATAACACCAACAAAGATCAAGCTGATACCC
ACAGTGAACTTGGAGTACGTCACCTGCCACTACAAAACAGGAATGGATTCACCAGCCATCAAATGCTGCG
GATCTCAGGAATGTACTCCAACTAACAGGCCTGATGAACAGTGCAAAGTCTTCACAGGGGTTTACCCGTT
CATGTGGGGAGGTGCATATTGCTTTTGCGACACTGAGAATACTCAGGTCAGCAAGGCCTACGTAATGAAA
TCTGACGACTGCCTTGCGGATCATGCTGAAGCATACAAAGCGCACACAGCCTCAGTGCAGGCGTTCCTCA
ACATCACAGTGGGGGAACACTCTATTGTGACCACCGTGTATGTGAATGGAGAAACTCCTGTGAACTTCAA
TGGGGTCAAACTAACTGCAGGTCCACTTTCCACAGCTTGGACACCCTTTGACAGAAAAATCGTGCAGTAT
GCCGGGGAGATCTATAATTACGATTTTCCTGAGTATGGGGCAGGACAACCAGGAGCATTTGGAGACATAC
AATCCAGAACAGTCTCAAGCTCAGATCTGTATGCCAATACCAACCTAGTGCTGCAGAGACCCAAAGCAGG
AGCGATCCATGTGCCATACACTCAGGCACCATCGGGTTTTGAGCAATGGAAGAAAGATAAAGCTCCGTCA
TTGAAATTCACCGCCCCTTTCGGATGCGAAATATATACAAACCCCATTCGCGCCGAAAATTGTGCTGTAG
GGTCAATTCCATTAGCCTTTGACATTCCCGACGCCTTGTTCACCAGGGTGTCAGAAACACCGACACTTTC
AGCGGCCGAATGCACTCTTAACGAGTGCGTGTATTCATCCGACTTTGGCGGGATCGCCACGGTCAAGTAT
TCGGCCAGCAAGTCAGGCAAGTGCGCAGTCCATGTGCCATCAGGGACTGCTACCCTAAAAGAAGCAGCAG
TCGAGCTAACCGAGCAAGGGTCGGCGACCATTCATTTCTCGACCGCAAATATCCACCCGGAGTTCAGGCT
CCAAATATGCACATCATATGTCACGTGCAAAGGTGATTGTCACCCCCCGAAAGACCACATTGTGACACAC
CCCCAGTATCACGCCCAAACATTTACAGCCGCGGTGTCAAAAACCGCGTGGACGTGGTTAACATCCCTGC
TGGGAGGATCGGCCGTAATTATTATAATTGGCTTAGTGCTGGCTACTATTGTGGCCATGTACGTGCTGAC
CAACCAGAAACATAATTGAACATAGCAGCAATTGGCAAGCTGCTTATATAGAACTTGCGGCGATTGGCAT
GCCGCTTTAAAATTTTATTTTATTTTCTTTTCTTTTCCGAATCGGATTTTGTTTTTAATATTT
Protein Information
Protein Name mRNA
NCBI Protein GI 9626528
Protein Accession NP_040824
Protein pI 8.88
Protein Weight 129183.21
Protein Length 1255
Protein Sequence 
>NP_040824.1 structural polyprotein precursor [Venezuelan equine encephalitis virus]
MFPFQPMYPMQPMPYRNPFAAPRRPWFPRTDPFLAMQVQELTRSMANLTFKQRRDAPPEGPPAKKPKREA
PQKQKGGGQGKKKKNQGKKKAKTGPPNPKAQSGNKKKPNKKPGKRQRMVMKLESDKTFPIMLEGKINGYA
CVVGGKLFRPMHVEGKIDNDVLAALKTKKASKYDLEYADVPQNMRADTFKYTHEKPQGYYSWHHGAVQYE
NGRFTVPKGVGAKGDSGRPILDNQGRVVAIVLGGVNEGSRTALSVVMWNEKGVTVKYTPENCEQWSLVTT
MCLLANVTFPCAEPPICYDRKPAETLAMLSVNVDNPGYDELLEAAVKCPGRKRRSTEELFKEYKLTRPYM
ARCIRCAVGSCHSPIAIEAVKSDGHDGYVRLQTSSQYGLDSSGNLKGRTMRYDMHGTIEEIPLHQVSLHT
SRPCHIVDGHGYFLLARCPAGDSITMEFKKGSVTHSCSVPYEVKFNPVGRELYTHPPEHGAEQACQVYAH
DAQNRGAYVEMHLPGSEVDSSLISLSGSSVTVTPPVGTSALVKCKCGGTKISETINKAKQFSQCTKKEQC
RAYRLQNDKWVYNSDKLPKAAGATLKGKLHVPFLLADGKCTVPLAPEPMITFGFRSVSLKLHPKNPTYLT
TRQLADEPHYTHELISEPAVRNFTVTEKGWEFVWGNHPPKRFWAQETAPGNPHGLPHEVITHYYHRYPMS
TILGLSICAAIVTVSVAASTWLFCKSRVSCLTPYRLTPNARMPLCLAVLCCARTARAETTWESLDHLWNN
NQQMFWIQLLIPLAALIVVTRLLKCVCCVVPFLVVAGAAGAGAYEHATTMPSQAGISYNTIVNRAGYAPL
PISITPTKIKLIPTVNLEYVTCHYKTGMDSPAIKCCGSQECTPTNRPDEQCKVFTGVYPFMWGGAYCFCD
TENTQVSKAYVMKSDDCLADHAEAYKAHTASVQAFLNITVGEHSIVTTVYVNGETPVNFNGVKLTAGPLS
TAWTPFDRKIVQYAGEIYNYDFPEYGAGQPGAFGDIQSRTVSSSDLYANTNLVLQRPKAGAIHVPYTQAP
SGFEQWKKDKAPSLKFTAPFGCEIYTNPIRAENCAVGSIPLAFDIPDALFTRVSETPTLSAAECTLNECV
YSSDFGGIATVKYSASKSGKCAVHVPSGTATLKEAAVELTEQGSATIHFSTANIHPEFRLQICTSYVTCK
GDCHPPKDHIVTHPQYHAQTFTAAVSKTAWTWLTSLLGGSAVIIIIGLVLATIVAMYVLTNQKHN
Epitope Information
IEDB Linear Epitope