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WbtI

General Information
Protegen ID 472
Sequence Strain (Species/Organism) Francisella tularensis subsp. holarctica FTNF002-00
VO ID VO_0011074
Taxonomy ID 458234
Molecule Role Protective antigen
Molecule Role Annotation Immunization with WbtI(G191V) protected mice against a relatively low-dose intraperitoneal challenge with LVS (F. tularensis subspecies holarctica live vaccine strain), but was less protective against a high-dose challenge (Li et al., 2007).
Additional Molecule Role Virmugen
Additional Molecule Role Annotation A wbtI mutant is attenuated in mice. The mutant protected against a low dose challenge with the parental strain, but was less effective against higher doses. However, increasing the immunization dose increased the resistance to higher challenge doses (Li et al., 2007).
COG COG0399M, under M: Cell wall/membrane/envelope biogenesis
Related Vaccines(s) Francisella tularensis wbtI mutant vaccine
References
Li et al., 2007: Li J, Ryder C, Mandal M, Ahmed F, Azadi P, Snyder DS, Pechous RD, Zahrt T, Inzana TJ. Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS. Microbiology (Reading, England). 2007; 153(Pt 9); 3141-3153. [PubMed: 17768257].
Gene Information
Gene Name WbtI
NCBI Gene ID 5522688
Genbank Accession CP000803
Locus Tag FTA_0635
Gene Starting Position 590832
Gene Ending Position 591914
DNA Sequence 
>NC_009749.1:590832-591914 Francisella tularensis subsp. holarctica FTNF002-00, complete genome
AATGAGTAAAGTAAATGTAACAAAACCATATTTACCAGATATAAATAAATATAAAAGCTATGTAAATAAA
ATATACAAAAATGGATGGCTTACTAATAATGGTCCGTTAGTGCAAGAGCTAGAAAAAAGACTTGCAAAGT
ATCTAGGTGTTAAAAATATAGTTTTAGTATCAAATGGTACAATTGCATTAGAAATCGCGTATAGAGCGTT
AGGAGTCAAAGGAAGTGCAATTACTACTCCATTTTCATTTGTCGCTACTACATCTTCATTGGTTTCTAAC
AATGTAAAACCAGTGTTTGTTGATATTGATGAGAATACTCTAAGTATAGACGTCTCTAAAATTAAGTATG
CTATTGAAGAGGATACTTCAGCTATTGTGCCAGTTCATGTGTTTGGAAATGGTTGTGAAGTTGAAAAAAT
AGACATGCTGGCTAAAAAACATAACTTAAAAGTTATTTATGATGCAGCACATGCTTTTGATGTTAAGTAT
AAGGGTGAGAGTATATTAAACTATGGTGATATTTCGACATTAAGTTTTCATGCAACAAAGATTTTTCATT
CTATTGAAGGAGGTGCGCTTATCATTAATGATGATAGTCTTGTTGAAAAAGTTCGTTATTTCATTAATTT
TGGTATAGAAAGCTCAGAATCAATACCTTACTTAGGTACTAATGCTAAAATGAATGAATTTGAGGCGGCT
ATGGGACTTTGTGTTCTAGATGATATTATAGAAATTAAGAGCAAAAGGAAAGTTATTACAGAGATATATG
AGGCTGGGTTAGATGGATTGGTAAAGTTTCAAGAACAGAATCAGCATTCTAGTAGGAATTATAGCTATTT
TCCAGTAATATTTAGGACTGAGGAGGAACTTCTCAGAGTACAGAAAGCACTAATACAAAATGATATAATA
TCGCGTAGATATTTTTATCCATCATTAGATAGTCTTAGTTATATAGAGCCAAAGCAGTATATGCCAATCT
CAAGAGATATATCTAAAAGAATATTATGTTTGCCAATTTATGCAGAGTTAGAAGACGATAAAATTAATAA
AATAATTAATAATATCAAAGAGGTTTCCTCATG
Protein Information
Protein Name DegT/DnrJ/EryC1/StrS family sugar aminotransferase
NCBI Protein GI 156502002
Protein Accession YP_001428067
Protein pI 6.8
Protein Weight 37905.36
Protein Length 360
Protein Note component of putative O antigen gene complex
Protein Sequence 
>YP_001428067.1 DegT/DnrJ/EryC1/StrS family sugar aminotransferase [Francisella tularensis subsp. holarctica FTNF002-00]
MSKVNVTKPYLPDINKYKSYVNKIYKNGWLTNNGPLVQELEKRLAKYLGVKNIVLVSNGTIALEIAYRAL
GVKGSAITTPFSFVATTSSLVSNNVKPVFVDIDENTLSIDVSKIKYAIEEDTSAIVPVHVFGNGCEVEKI
DMLAKKHNLKVIYDAAHAFDVKYKGESILNYGDISTLSFHATKIFHSIEGGALIINDDSLVEKVRYFINF
GIESSESIPYLGTNAKMNEFEAAMGLCVLDDIIEIKSKRKVITEIYEAGLDGLVKFQEQNQHSSRNYSYF
PVIFRTEEELLRVQKALIQNDIISRRYFYPSLDSLSYIEPKQYMPISRDISKRILCLPIYAELEDDKINK
IINNIKEVSS
Epitope Information
IEDB Linear Epitope