VIOLIN: Vaccine Investigation and Online Information Network

ompW

General Information

Protegen ID

4091

Sequence Strain (Species/Organism)

Actinobacillus pleuropneumoniae

Taxonomy ID

715

Other Database IDs

CDD:328747

Molecule Role

Protective antigen

Molecule Role Annotation

APJL_0126, HbpA and OmpW were further tested in the natural host (swine) by homologous and heterologous challenges., showing that these proteins could induce high titers of antibodies, but vaccination with each protein individually elicited low protective immunity against A. pleuropneumoniae.(Chen et al., 2012)

Related Vaccines(s)

A. pleuropneumoniae OmpW vaccine

References

Chen et al., 2012: Chen X, Xu Z, Li L, Chen H, Zhou R. Identification of conserved surface proteins as novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Journal of microbiology (Seoul, Korea). 2012; 50(6); 978-986. [PubMed: 23274984].

Gene Information

Gene Name

ompW

Protein Information

Protein Name

Outer membrane protein W

NCBI Protein GI

ASU14913

Protein pI

8.7

Protein Weight

21467.67

Protein Length

291

Protein Note

Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; cl21487

Protein Sequence

>ASU14913.1 Outer membrane protein W [Actinobacillus pleuropneumoniae]
MKKAVLAAVLGGALLADSAMAHQAGDVIFRAGAIGVIANSSSDYQTGADVNLDVNNNIQLGLTGTYMLSD
NLGLELLAATPFSHKITGKLGATDLGEVAKVKHLPPSLYLQYYFFDSNATVRPYVGAGLNYTRFFSAESL
KPQLVQNLRVKKHSVAPIANLGVDVKLTDNLSFNAAAWYTRIKTTADYDVPGLGHVSTPITLDPVVLFSG
ISYKF

Epitope Information

IEDB Linear Epitope