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TNFRSF18

General Information
Protegen ID 294
Sequence Strain (Species/Organism) Homo sapiens
Taxonomy ID 9606
Molecule Role Protective antigen
Molecule Role Annotation Ligation of GITR (TNFRSF18) with DTA-1 just before the second, but not the first, of 3 weekly DNA immunizations enhanced primary CD8(+) T-cell responses against the melanoma differentiation antigens gp100 and tyrosinase-related protein 2/dopachrome tautomerase and increased protection from a lethal challenge with B16 melanoma (Cohen et al., 2006).
Related Vaccines(s) Sargramostim Plasmid DNA Melanoma Vaccine Adjuvant
References
Cohen et al., 2006: Cohen AD, Diab A, Perales MA, Wolchok JD, Rizzuto G, Merghoub T, Huggins D, Liu C, Turk MJ, Restifo NP, Sakaguchi S, Houghton AN. Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. Cancer research. 2006; 66(9); 4904-4912. [PubMed: 16651447].
Gene Information
Gene Name TNFRSF18
NCBI Gene ID 8784
Genbank Accession AL162741
Chromosome No 1
Gene Starting Position 1203507
Gene Ending Position 1207900
DNA Sequence 
>NC_000001.11:1203507-1207900 Homo sapiens chromosome 1, GRCh38.p12 Primary Assembly
GTCACTGGACAAGTGTTTATTGAAGGTCCCCTGCAGCCGGGTCCCGTGCTGGGCACTGCACACCCACGGA
CACAGCCTCCCGTCCTAAGACCCCACCCCATCAGGGCCAGCAAGGGAGGAAGGGGGCCATGACTGTGTCT
CTCTCTCCCTCCTGCAGGGCCCAGCCGCGGCCGCCGAACTGCATGGTCCAGGGCGCTGGTCACTGCCACC
TTCCTGCACCCACTTCTGCTGCCAGGGGAGCAGGGCCCGGCCCAGAGCAGAACGCAGAGCCCCTGCGGCC
TGGGGAGCTCCTGGGGAGGGGCTGGCTGCGGTCGGTGGCCCCGGAGGACGGCCAGGCTCACACCCACAGG
TCTCCCAGCCGCCCCTTCTCCTCTGCCGATCGCTCGCCCCGCTCTTCCTCGGGGAACTGGCAGCTTCTGG
CGTCTTCGGTCGACGGCGGCACCTCCAGCAGCAGCTGGGTCTCTGCAGGGGGGCCACGGTCAGCAGGCAG
CCATGCTCCCACCTCCCCGCACCAGGCTGTGACAGACCTCGGGGCCACATGCACTGACTCCTCAGCTGCC
AGATGTGCAGTCCAAGCTGGGCCGAGGTCAGGAGGAGGACGCAGGCGGCCACGGCCAGGAGGACGACGGT
CAGCCACCCAAGCGGCTCTGCCGGCGGGGACCCTGGGACGCACACAGCGTTGTGGGTCTTGTTCCCAGGG
AACACAGTGAGAAACCCGAACTGGGTGCAGCTGGAATACATGGACGCGGCCTCCTATCAGCCCCCGGACA
CGGCCTCCGATCAGCCCCCGGCTGCTGCCCTCCGTGCTGTCTGGGGCAAGGGACAGGAGAGGACCCTTCC
TCAGAGTGGGCCTGGACCACCCGGCCACCGGCAGGGCCCACCCAGGACTCACTCTGTCCAAGGTTTGCAG
TGGCCTTCGTGGCCCCCGGAGAAGGTCCCCGAGGCACAGTCGATACACTGGAAGCCAAAACTGAATTTCC
CTGGTGTGGGGTGTGGGGGGAGGGAGGGAGGGAGGCTGGTGGAGTTGCTGGGATGGATGAGGAGGGCGTC
AGGCCAGTGCAGGGGTCCATCTGGGGTCTGGGTGCTGAGTAGAATGCCCCCCCCATCATCCATTCAACAG
AGTTCTTCATGGCCCAGGACTGGGGCCCATGTCTGCCCGTCCCAGGTGGGGCGTCTGGGGTGGGGCCCAG
TGAGGGCACCTGGGGGAGGTGCGCAGAGTGCAGTGGGCCTGCCAGGGAGGGGAAAGGCCTGCCCATTGGG
GGCTGAGGGTGGGCAGAAGCCAGGCAGGACCCAGTAGAACAGAGGGTGGAGAACAGTGAGGGTCCCAGAG
AGAGTGAGGCTGGGTCCCAGTTGACCCCAGACCCTGCCCCGTCCAACCTGACACAACCTCCCCAGTTGTA
CCTTCTCCCAGCTCTCATGTGCCCAGCCTGACCTCTCCTGTCAGGTAAACAAGCCGCTAAGAGGACTTGA
GCTGCTCCTTCCAGAACAGGGTGCAGCCCCAGGCCCCAGACAGGACTCCGGGGGGCACAGGGCAGGCTCT
TTCAGTATGTGGTGAGGACAGACAGGATGGGTGTCCCGGGCCTGAGAGCCAGACAGCTCCTGGAACCCGC
CCCCACCTCCCCGCAGGGTTCTCACAGCCCTCGTGCTGGATGGAGAAGCCCAGGCTGAGAAAGCAGGGAC
AGGACACCCCCAGAGCTTCATGGCCTGTGGTGCCTGAGCATGGCCTGGCCTGCCCGGCCTCACAGGACTC
CGGACCCCACACACCACATGTCCTCGCCGGACACCTGTGCCCACGAGCTCTGCCTCGGGCCCTAGTGGAA
CCCCTGGCCTGTGTGGACTCCCAGAGGCACCTCCAGGACTTACCCTGGGACTGTACCCCCTGGCCTGGGG
GACAAGGGTGGTGCCGGCAGGTCGTGCAGCAAGGGTCTCCGCAGTGGAATTCAGGCTGGACACACATGCA
GTCCCACTCGGAACAGCACTCCTCGCCTGGGCAGGAGACAGGCCAGCCCCCCAGCAGCTGGGCTGAGGCC
CCCTCCTCCCCAGGCCTCCCCTCGGCCCTCCAGGGGAGTGAGGTTGTCCGTTCTCCACCCACAGTTGGCT
CCAGGGAGCAGAGGGCTCCTGGCTGGGAGTCTGGACCCTGGGTTTATCCAGCTGTCTCTTTCTCCTGGGG
CCATGTGGCCTGGCTACTCCCCCTTTGCGCCCCACAGCTGCCCCTGCCCAGGTGCTAACTCCATATGCAA
CCAGGAGCTGCCCCTGCAGGACCCAGGGGTGGCCCCCAACAGTGCACAGTCCCCTGGAGGCCCGTCGACA
CCTCAGAGGCCGCCTGCCTGGTGTCTGGGCGCTGCTGTCCCCACCACCAGCCACACTGGGCCTCCGGACA
GAGCCTCCCTTCCCAACCCACAGGCCCTGGAGGAAGAAGCTCTGGGGTGACTTCCCTGCCAGCTTCCTCT
CCAGACCAGCCGTGTCAGCTGAACCCTCATCCCCAGGTGCAGGTCAGAGGCAGGCAGCAGGCCAGACGGT
GGTGCAGGGGGGCCCTCAACTGGGCAGGAGGGGGCTGGGCGATGGCCAAGGGCTCACGACCCGCCCAGCA
GGACCTGGAACAGCCGTCCTCCACCTCCAGACCCCAGACCCCTCTTGAGGGCGCTCCCACCTGGCTCACC
CCTGCTCCCGGCCGGGGCCACTGGCTGGAGCTGGCACACCTCCGCCTCCCTCTGGGATCCTGCCTCCCTC
CGGAAGGCTCCCGCTGCTGGCGGCTCTGTGCCCACCCTCCTTAGACCTCAGCAACGCCGGTCTGAGCACG
GGAAGGGGGGCGCCCACCCATCCCGGCTTCCGCGGGACGCCTTGGCCGGTCCGCGTTAAGTAAACGCGGT
TTACTTACCCGGGTAATCGCGGCAGCAGCGCGTCGTGTGAACCCGGCAGCAGCGCGCGTCCGTTCCCGTC
CCAAGCAGGAGGCGCCCAGGGCCGCACCCGGGACCCCCGGTGGGGCGCTGACCCAGGCTGAGCGCGCACA
GCAGCGCCAGGCCGCACAGGGCCCGAAACGCGCCCATCGCCCCGTGCTGTGCCATGCTCGGGTTTCAAGA
GCCCACAGCCAGTTGGACACGCCCCGTCCCCGTCCTCACCCGCCCTGCCCGGAGGTGGCTGGGACCGTTC
ATGACCTGAGAATCCCGACCCAGGTGAAGTGCGTGTGAGGAGGGGGTGTAGACACTGCGGACACAGCCCG
GTCCCCCGCAGGTCGCCGGCAGGGGCGGGGAAACCAGGCTGGCGGGGATCAGAAAGGTTTTCTATGCAAA
GTCTGCGGCCACATTGGTGTCCCCAGTGCAGGGGGCGGCGTTTATAGCACCTTGTCCCATGGGGGCCCCT
TGGAGGGCGGGGGTCAGCCAATCACTCCTCCATCCCACTGCCTCCGGGTGGTATCTGCGAGTCCCCGAGA
GGTCTCCACAAATTCTGGCCACCCCCAGAGAGCCTCAACCATGGAGCCCCGTGCTGGGGAACCCCACAGA
ATGGGGACAGGGACCCCTCGGCTCAGCACACCCCACCTGGCTGGCTTCAGGTGTGAAACTCACCATGGGC
TGCAGGCCTGTGGGCTCCCCTCCCCCTTGCTTGCAGCTCTCCAGGACCCCCCTCAGGCCAACCTGGGAAG
TTCCCCGGGGCTTGGGAGGGGCACCAGGAGGAGCTGGTGGGGAGACGAGAGGGTGCTGGCGCCTCCTCGG
GACAGTGTCAGCCGCCCCCGCGGGCACCCAGGGCCCGGTCTCTCAGAGCCACCTTCATCCGTCACACCAG
ACAGATCCAGGTCCCGGAGGGAGTTGAGGAGGAGCCCCTCGCAGAGCTCTTGGGAGACTGTCCTATGTCT
TTCTGAGCCTCAGTTTCCCCTGTGGGCACCGAGGGGTTCTGGGACCCTGCCTCCACCAGGAAGCCTCCCT
GGATTGCCCAGCCCTGCTTCTGCGCCGTCCAGCACAGGTGGAGACCCCCATGAATGCTGGGGGTGGGGGC
TCTCGGGAACGTGAGCGTGGATGTGGTTCAACACCCTTTTGAGACCTGCAGCCACCGCCTCACCCCGTAA
GGCGGTTCCTCCTTTTCCAAGGTAAATGACAGGAATTAGCTGTTTGTGACACCCCGGAGTTCTCAAATCC
AAGATGTAGGAGCCTGCCTTGGAGAGGCAGCCCTCAGACACTGCAGAGAAGGAAGGGGTCTCTGCAGCTC
CAGGCCGCCCCGACGCTCGGAAGGAAAGGGGTGGGGCCAGCTGGGCCTGGGGGCCTTTGAGAGGCCTGGA
GATCTTCAGCCCCGAGGCTGGGAGGGGGTCTGGGCCCCTGGATAGAAAGAGGCGCCATCAGTGGCTCACG
CCCGTAATCCCAGCATTTTGGGAGGCCGAGGTGGGCCTCGGATCACCTGAGGTC
Protein Information
Protein Name transcript variant X1
NCBI Protein GI 4759246
Protein Accession NP_004186
Protein pI 6.39
Protein Weight 24808
Protein Length 241
Protein Sequence 
>NP_004186.1 tumor necrosis factor receptor superfamily member 18 isoform 1 precursor [Homo sapiens]
MAQHGAMGAFRALCGLALLCALSLGQRPTGGPGCGPGRLLLGTGTDARCCRVHTTRCCRDYPGEECCSEW
DCMCVQPEFHCGDPCCTTCRHHPCPPGQGVQSQGKFSFGFQCIDCASGTFSGGHEGHCKPWTDCTQFGFL
TVFPGNKTHNAVCVPGSPPAEPLGWLTVVLLAVAACVLLLTSAQLGLHIWQLRSQCMWPRETQLLLEVPP
STEDARSCQFPEEERGERSAEEKGRLGDLWV
Epitope Information
IEDB Linear Epitope