Omp25
General Information
Protegen ID
253
Sequence Strain (Species/Organism)
Brucella melitensis bv. 1 str. 16M
VO ID
VO_0010966
Taxonomy ID
224914
Molecule Role
Protective antigen
Molecule Role Annotation
Brucella Omp25 is a protective antigen (Commander et al. , 2007 ).
Additional Molecule Role
Virmugen
Additional Molecule Role Annotation
A omp25 mutant is attenuated and provides protection against challenge in mice (Edmonds et al. , 2002 ).
COG
COG3637M, under M: Cell wall/membrane/envelope biogenesis
Related Vaccines(s)
B. melitensis DNA vaccine p-Omp25
,
Brucella melitensis omp25 mutant vaccine
References
Commander et al. , 2007: Commander NJ, Spencer SA, Wren BW, MacMillan AP. The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genes. Vaccine . 2007; 25(1); 43-54. [PubMed: 17049676 ].
Edmonds et al. , 2002: Edmonds MD, Cloeckaert A, Elzer PH. Brucella species lacking the major outer membrane protein Omp25 are attenuated in mice and protect against Brucella melitensis and Brucella ovis . Veterinary microbiology . 2002; 88(3); 205-221. [PubMed: 12151196 ].
Gene Information
Gene Name
Omp25
NCBI Gene ID
1196960
Genbank Accession
AE008917
Chromosome No
I
Locus Tag
BMEI1249
Gene Starting Position
1297524
Gene Ending Position
1298165
DNA Sequence
>NC_003317.1:1297524-1298165 Brucella melitensis bv. 1 str. 16M chromosome I, complete sequence
ATTAGAACTTGTAGCCGATGCCGACGCGGAAATCCTGCGTGTCCAGCTTGTTGCGAACAGTCGTACCGGC
CAGATCATAGTTCTTGTTGCCGTACTGGGTGTAACGGTACTCAACGCGGCCGAGGATGTTGTCCGTCAGC
TTGGCTTCGAGACCGGCACCAGCCGTCCAACCCACGCGGAACTTGCTTTCGTCGTCCAAGCCGTTGTTAA
GCTTGATCTGCGAACCGGCAATACCAGCCGTGAGGTACGGCATAACCGGGTTCAGGTCGTAGCCAACGCG
GGCACGCAGCGAGCCTTCAAAGCCCTGCTTGACTTCCAGGCCGTCCTTGGACTTCTTGGCCCAGGAATAA
CCTGCATCACCTTCAACACCGTATACGATCTGGTCCTGCTGGAAGTTCCAGCCAGCAAAGGCGCCAGCCT
TCCAATCGTCAGGCTTGATGCTGCCAACGGTGCTGGTCTTGGCCTTGTTCCAGCCGTAGCCAAGGTAAAG
ACCGGTATAGCCACCAGCCCAGCTATACTGGGGAGCTACTTCAACCGGAGCCGGAACCGGAGGCTGTTCC
TGGATGGCGTCGGCAGCAAAAGCGGTCGCAGAGAACGGCAGCAACGCAGCCGAGACGATTACGAGAGACT
TAAGAGTGCGCA
Protein Information
Protein Name
hypothetical protein
NCBI Protein GI
17987532
Protein Accession
NP_540166
Protein pI
9.03
Protein Weight
21696.72
Protein Length
213
Protein Annotation
Reference: http://www.ncbi.nlm.nih.gov/pubmed/17049676
Protein Sequence
>NP_540166.1 hypothetical protein BMEI1249 [Brucella melitensis bv. 1 str. 16M]
MRTLKSLVIVSAALLPFSATAFAADAIQEQPPVPAPVEVAPQYSWAGGYTGLYLGYGWNKAKTSTVGSIK
PDDWKAGAFAGWNFQQDQIVYGVEGDAGYSWAKKSKDGLEVKQGFEGSLRARVGYDLNPVMPYLTAGIAG
SQIKLNNGLDDESKFRVGWTAGAGLEAKLTDNILGRVEYRYTQYGNKNYDLAGTTVRNKLDTQDFRVGIG
YKF
Vaxign Prediction
Localization(Probability)
Outer Membrane (Prob.=1)
Adhesin Probability
0.574
Trans-membrane Helices
0
Detailed Vaxign Results
Vaxign Results
Epitope Information
IEDB Linear Epitope
-- Assay Type --
T Cell Epitope
B Cell Epitope
IEDB ID
Epitope
Starting position
Ending position
MRTLKSLVIVSAALLPFSATAFAADAIQEQPPVPAPVEVAPQYSWAGGYTGLYLGYGWNKAKTSTVGSIKPDDWKAGAFAGWNFQQDQIVYGVEGDAGYSWAKKSKDGLEVKQGFEGSLRARVGYDLNPVMPYLTAGIAGSQIKLNNGLDDESKFRVGWTAGAGLEAKLTDNILGRVEYRYTQYGNKNYDLAGTTVRNKLDTQDFRVGIGYKF