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Vaccine Comparison
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rBCG-SIVgag |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004789
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Macaque
- Antigen: M. bovis BCG-SIV Gag followed by boosting with rDIsSIVgag (Ami et al., 2005).
- gag
gene engineering:
- Type: Recombinant vector construction
- Description: The SIV gag gene was used in generation of a recombinant vector vaccine (Ami et al., 2005).
- Detailed Gene Information: Click Here.
- Vector:
- Immunization Route: Intradermal injection (i.d.)
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| References |
Ami et al., 2005: Ami Y, Izumi Y, Matsuo K, Someya K, Kanekiyo M, Horibata S, Yoshino N, Sakai K, Shinohara K, Matsumoto S, Yamada T, Yamazaki S, Yamamoto N, Honda M. Priming-boosting vaccination with recombinant Mycobacterium bovis bacillus Calmette-Guérin and a nonreplicating vaccinia virus recombinant leads to long-lasting and effective immunity. Journal of virology. 2005; 79(20); 12871-12879. [PubMed: 16188989].
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rMVA-SIV-CD40L |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004664
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Immunization Route: Intramuscular injection (i.m.)
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| References |
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SabRV-SIV |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004704
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- env
gene engineering:
- Type: Recombinant vector construction
- Description: To construct pSabRV1, first the EcoRI and XhoI sites upstream of the T7 promoter of pS1 were eliminated to create plasmid pS1XT. Then the 747-bp BstEII fragment of pMoV2.11—containing the duplicated 2Apro cleavage site, the 5-glycine spacer, and the EcoRI, NotI, and XhoI cloning sites—was swapped into pS1XT to create pSabRV1 (Crotty et al., 2001).
- Detailed Gene Information: Click Here.
- env receptor binding subunit
gene engineering:
- Type: Recombinant vector construction
- Description: To construct pSabRV1, first the EcoRI and XhoI sites upstream of the T7 promoter of pS1 were eliminated to create plasmid pS1XT. Then the 747-bp BstEII fragment of pMoV2.11—containing the duplicated 2Apro cleavage site, the 5-glycine spacer, and the EcoRI, NotI, and XhoI cloning sites—was swapped into pS1XT to create pSabRV1 (Crotty et al., 2001).
- Detailed Gene Information: Click Here.
- gag-pol
gene engineering:
- Type: Recombinant vector construction
- Description: To construct pSabRV1, first the EcoRI and XhoI sites upstream of the T7 promoter of pS1 were eliminated to create plasmid pS1XT. Then the 747-bp BstEII fragment of pMoV2.11—containing the duplicated 2Apro cleavage site, the 5-glycine spacer, and the EcoRI, NotI, and XhoI cloning sites—was swapped into pS1XT to create pSabRV1 (Crotty et al., 2001).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: New poliovirus vectors based on Sabin 1 and 2 vaccine strain viruses were constructed, and these vectors were used to generate a series of new viruses containing SIV gag, pol, env, nef, and tat in overlapping fragments (Crotty et al., 2001).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Crotty et al., 2001: Crotty S, Miller CJ, Lohman BL, Neagu MR, Compton L, Lu D, Lü FX, Fritts L, Lifson JD, Andino R. Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors. Journal of virology. 2001; 75(16); 7435-7452. [PubMed: 11462016].
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SIV recombinant vector vaccine rAd5/rLCMV |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004564
- Type: Recombinant vector vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaques
- Antigen: a mismatched SIV envelope (Env) gene derived from simian immunodeficiency virus SIVmac239 (Flatz et al., 2012)
- Vector:
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Flatz et al., 2012: Flatz L, Cheng C, Wang L, Foulds KE, Ko SY, Kong WP, Roychoudhuri R, Shi W, Bao S, Todd JP, Asmal M, Shen L, Donaldson M, Schmidt SD, Gall JG, Pinschewer DD, Letvin NL, Rao S, Mascola JR, Roederer M, Nabel GJ. Gene-based vaccination with a mismatched envelope protects against simian immunodeficiency virus infection in nonhuman primates. Journal of virology. 2012; 86(15); 7760-7770. [PubMed: 22593152].
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