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Vaccine Comparison
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BCG-DHTM |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004618
- Type: Recombinant vector vaccine
- Status: Research
- Antigen: BCG vaccine with deficient urease; a fusion protein composed of Mycobacterium tuberculosis-derived major membrane protein II (MMP-II) and heat shock protein 70 (HSP70) of BCG (Mukai et al., 2014).
- DnaK
gene engineering:
- Type: Recombinant vector construction
- Description: The M. tuberculosis gene dnaK, also known as hsp70, is a part of a fusion gene composed of the M. tuberculosis-derived MMP-II gene and the hsp70 gene of M. tuberculosis (locus tag: Rv0350). This fusion gene is introduced into the urease-deficient BCG-deltaUT-11-3 strain (Mukai et al., 2014).
- Detailed Gene Information: Click Here.
- bfrA
gene engineering:
- Type: Recombinant vector construction
- Description: The M. tuberculosis gene bfrA (also known as MMP-II) is a part of a fusion gene composed of the M. tuberculosis-derived MMP-II gene and the hsp70 gene of M. tuberculosis (locus tag: Rv0350). This fusion gene is introduced into the urease-deficient BCG-deltaUT-11-3 strain (Mukai et al., 2014).
- Detailed Gene Information: Click Here.
- Vector:
- Immunization Route: subcutaneous injection
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| References |
Mukai et al., 2014: Mukai T, Tsukamoto Y, Maeda Y, Tamura T, Makino M. Efficient activation of human T cells of both CD4 and CD8 subsets by urease-deficient recombinant Mycobacterium bovis BCG that produced a heat shock protein 70-M. tuberculosis-derived major membrane protein II fusion protein. Clinical and vaccine immunology : CVI. 2014; 21(1); 1-11. [PubMed: 24152387].
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LT-BCG- Ag85B /Rv3425 |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004626
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Ag85B from M. tuberculosis H37Rv
gene engineering:
- Type: Recombinant vector construction
- Description: DNA-, protein- and lentiviral vector-based vaccines that express the antigens Ag85B and Rv3425 (Xu et al., 2014).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: DNA-, protein- and lentiviral vector-based vaccines that express the antigens Ag85B and Rv3425 (Xu et al., 2014).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Xu et al., 2014: Xu Y, Yang E, Wang J, Li R, Li G, Liu G, Song N, Huang Q, Kong C, Wang H. Prime-boost BCG vaccination with lentivirus-vectored and DNA-based vaccines expressing antigens Ag85B and Rv3425 improves protective efficacy against M. tuberculosis in mice. Immunology. 2014; ; . [PubMed: 24773322].
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M.S-Δesx-3-IKEPLUS (M. tuberculosis) |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004689
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- Vector:
- Preparation: (Sweeney et al., 2011)
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Sweeney et al., 2011: Sweeney KA, Dao DN, Goldberg MF, Hsu T, Venkataswamy MM, Henao-Tamayo M, Ordway D, Sellers RS, Jain P, Chen B, Chen M, Kim J, Lukose R, Chan J, Orme IM, Porcelli SA, Jacobs WR Jr. A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nature medicine. 2011; 17(10); 1261-1268. [PubMed: 21892180].
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rBCG-Ag85A/ Ag85B |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004757
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Baboon
- FbpA (Ag85A)
gene engineering:
- Type: Recombinant vector construction
- Description: rBCG strains overexpressing immunodominant antigens Ag85B (rBCG::85B), Ag85A (rBCG::85A), or both (rBCG::AB) of Mycobacterium tuberculosis were constructed (Wang et al., 2012).
- Detailed Gene Information: Click Here.
- Ag85B from M. tuberculosis H37Rv
gene engineering:
- Type: Recombinant protein preparation
- Description: rBCG strains overexpressing immunodominant antigens Ag85B (rBCG::85B), Ag85A (rBCG::85A), or both (rBCG::AB) of Mycobacterium tuberculosis were constructed (Wang et al., 2012).
- Detailed Gene Information: Click Here.
- Vector:
- Preparation: Three rBCG strains overexpressing immunodominant antigens Ag85B (rBCG::85B), Ag85A (rBCG::85A), or both (rBCG::AB) of Mycobacterium tuberculosis (Wang et al., 2012).
- Immunization Route: Intramuscular injection (i.m.)
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| References |
Wang et al., 2012: Wang C, Fu R, Chen Z, Tan K, Chen L, Teng X, Lu J, Shi C, Fan X. Immunogenicity and protective efficacy of a novel recombinant BCG strain overexpressing antigens Ag85A and Ag85B. Clinical & developmental immunology. 2012; 2012; 563838. [PubMed: 22570667].
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