Ty Particles vaccine adjuvant |
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Vaxjo ID |
99 |
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Vaccine Adjuvant Name |
Ty Particles vaccine adjuvant |
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Alternative Names |
Ty-VLPs, (Virus Like Particles) |
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Adjuvant VO ID |
VO_0001352
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Description |
Ty particles present antigen in a polyvalent, particulate form. Cytotoxic T-lymphocytes are induced in the absence of any other adjuvant formulations (Vogel and Powell, 1995). |
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Stage of Development |
Research |
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Structure |
Amino acids 1-381 of the pl protein encoded by the yeast retrotransposon Ty, followed by a unique restriction site for the insertion of foreign sequences and a translational stop codon. Sequence of the p1 Ty protein:
MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEKASTKANSQQTTPASSAVPENP HHASPQTAQSHSPQNGPYPQQCMMTQNQANPSGWSFYGHPSMIPYTPYQMSPMYFPPGPQSQFP QYPSSVGTPLRT'PSPESGNTFTDSSSADSDMTSTKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLG GIIPTVNGKPVRQITDDELTFLYNTFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEAN DIVTLANLQYNGSTPADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLN MTVAELFLDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTrKPKAGS K* (Vogel and Powell, 1995). |
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Molecular Weight |
Monomer 42 kD |
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Appearance |
Clear aqueous solution. |
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Storage |
Store purified Ty particles at -20° C. Particles formulated with aluminum hydroxide should not be frozen, and can be stored at 4°C for 1-2 years (Vogel and Powell, 1995). |
| Related Vaccine(s) |
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| References |
Vogel and Powell, 1995: Vogel FR, Powell MF. A compendium of vaccine adjuvants and excipients. Pharmaceutical biotechnology. 1995; 6; 141-228. [PubMed: 7551218].
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