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AS03 |
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Vaxjo ID |
76 |
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Vaccine Adjuvant Name |
AS03 |
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Adjuvant VO ID |
VO_0001320
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Description |
AS03 (for "Adjuvant System 03") is the trade name for a squalene-based immunologic adjuvant used in various vaccine products by GlaxoSmithKline (GSK) (Wiki: AS03) |
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Stage of Development |
Licensed |
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Location Licensed |
Europe |
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Host Species for Testing |
2 |
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Components |
squalene, DL-α-tocopherol and polysorbate 80 (Wiki: AS03) |
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Preparation |
AS03 contains α-tocopherol and squalene, two biodegradable polyprenyls, in an o/w emulsion (Morel et al., 2011). |
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Function |
The ability of AS03 to enhance antigen-specific antibody responses was transient and localised to the injection site and coincided with the induction of an innate immune response (Morel et al., 2011). |
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| References |
Morel et al., 2011: Morel S, Didierlaurent A, Bourguignon P, Delhaye S, Baras B, Jacob V, Planty C, Elouahabi A, Harvengt P, Carlsen H, Kielland A, Chomez P, Garçon N, Van Mechelen M. Adjuvant System AS03 containing α-tocopherol modulates innate immune response and leads to improved adaptive immunity. Vaccine. 2011; 29(13); 2461-2473. [PubMed: 21256188].
Wiki: AS03: Wiki: AS03 [http://en.wikipedia.org/wiki/AS03]
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