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CYT387 |
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Vaxjo ID |
497 |
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Vaccine Adjuvant Name |
CYT387 |
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Adjuvant VO ID |
VO_0005774
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Description |
synthetic TBK1 inhibitor that leads to enhanced replication of viral vaccines |
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Stage of Development |
Research |
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Location Licensed |
Switzerland |
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Function |
Type: synthetic vaccine adjuvant. CYT387 interferes with antiviral signaling by inhibiting TANK-binding kinase 1 (TBK1).This inhibition of TBK1 leads to the suppression of type I interferon (IFN) signaling, which in turn allows for the replication of viral vaccines |
| References |
Sharma et al., 2020: Sharma S, Schmid MA, Sanchez Felipe L, Grenelle J, Kaptein SJF, Coelmont L, Neyts J, Dallmeier K. Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine. Human vaccines & immunotherapeutics. 2020; 16(9); 2196-2203. [PubMed: 32574095].
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