DOC/Alum Complex |
|
Vaxjo ID |
49 |
|
Vaccine Adjuvant Name |
DOC/Alum Complex |
|
Alternative Names |
Deoxycholic Acid Sodium Salt; DOC /Al(OH)3/ mineral carrier complex |
|
Adjuvant VO ID |
VO_0001291
|
|
Description |
DOC has been used as a detergent. Complex used as adjuvant formulation (Vogel and Powell, 1995). |
|
Stage of Development |
Research |
|
Components |
Deoxycholic Acid Sodium Salt; DOC /Al(OH)3/ mineral carrier complex (Vogel and Powell, 1995). |
|
Molecular Weight |
414.6 |
|
Appearance |
White powder, or a clear, colorless solution (Vogel and Powell, 1995). |
|
Storage |
4° C |
|
Function |
Enhances immune response to membrane proteins. Reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of b-catenin signaling (Vogel and Powell, 1995). |
|
Safety |
Effective concentration 5-50 µM (Pubchem: Deoxycholic Acid). |
| Related Vaccine(s) |
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| References |
Pubchem: Deoxycholic Acid: Deoxycholic Acid - Compound Summary [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=23668196&loc=ec_rcs]
Vogel and Powell, 1995: Vogel FR, Powell MF. A compendium of vaccine adjuvants and excipients. Pharmaceutical biotechnology. 1995; 6; 141-228. [PubMed: 7551218].
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