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MIP-1alpha |
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Vaxjo ID |
482 |
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Vaccine Adjuvant Name |
MIP-1alpha |
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Adjuvant VO ID |
VO_0005759
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Description |
chemokine vaccine adjuvant that induces Th1-biased response |
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Stage of Development |
Research |
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Location Licensed |
United States |
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Host Species for Testing |
Mouse |
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Components |
chemokine MIP-1 alpha |
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Preparation |
plasmids containing chemokine vector inserted into the pCI-neo mammalian expression vector |
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Function |
Type: cytokine vaccine adjuvant. Induces Th1-biased immune profile. activation of APCs which causes expression of costimulatory molecules B7-1 and B7-2 on APC surfaces, activating T cells |
| References |
Eo et al., 2001: Eo SK, Lee S, Chun S, Rouse BT. Modulation of immunity against herpes simplex virus infection via mucosal genetic transfer of plasmid DNA encoding chemokines. Journal of virology. 2001; 75(2); 569-578. [PubMed: 11134269].
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