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TFPR1 |
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Vaxjo ID |
474 |
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Vaccine Adjuvant Name |
TFPR1 |
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Adjuvant VO ID |
VO_0005751
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Description |
PR-1 domain of triflin, protein found in Habu snake venom, that induces Th1 response |
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Stage of Development |
Research |
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Location Licensed |
China |
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Host Species for Testing |
Mouse |
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Components |
residues 31-175 of triflin's core protein domain |
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Preparation |
Triflin’s structure and homology were modeled using SWISS-MODEL. The codon-optimized gene was cloned into pET-His7, expressed in E. coli, purified by Ni-NTA chromatography, endotoxin-removed with Detoxigel™, and verified for purity and low endotoxin levels before use |
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Function |
Type: animal-derived vaccine adjuvant. Target Receptor: Toll-like receptor 2 (TLR2). Induces Th1-biased immune profile. binding and engaging Toll-like receptor 2 (TLR2) on immune cells, which leads to the activation of dendritic cells and enhances antigen presentation. |
| References |
Li et al., 2021: Li Q, Liu Z, Liu Y, Liang C, Shu J, Jin X, Li C, Kou Z. A Combined Adjuvant TF-Al Consisting of TFPR1 and Aluminum Hydroxide Augments Strong Humoral and Cellular Immune Responses in Both C57BL/6 and BALB/c Mice. Vaccines. 2021; 9(12); . [PubMed: 34960154].
Sun et al., 2020: Sun W, Li Q, Ning X, Yang Y, Guo J, Zhu Q, Guo Y, Li H, Wang Y, Zhou Y, Kou Z. TFPR1 acts as an immune regulator and an efficient adjuvant for proteins and peptides by activating immune cells, primarily through TLR2. Vaccine. 2020; 38(2); 288-297. [PubMed: 31629567].
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