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Specol |
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Vaxjo ID |
44 |
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Vaccine Adjuvant Name |
Specol |
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Adjuvant VO ID |
VO_0001314
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Description |
Specol is a water-in-oil emulsion that is used as an adjuvant and has immunostimulating properties similar to Freund's complete adjuvant (FCA) (Boersma et al., 1992). |
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Stage of Development |
Research |
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Components |
Marcol 52 (mineral oul, paraffins, cycloparaffins, and chain length 13-22 C atoms), Span 85 (emulsifier, sorbitan trioleate), Tween 85 (emulsifier, polyoxyethylene-20-trioleate) (Vogel and Powell, 1995). |
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Function |
It functions as a depot (slow release of antigen) and a polyclonal activator (independent of presence of antigen) for cells of the immune system (cytokine release)(Vogel and Powell, 1995). |
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Safety |
No known use in humans, registered for veterinary use by itself or in combination with vaccines (Vogel and Powell, 1995). Causes mild reactions in animals, Specol has far less adverse reactions than FCA (Boersma et al., 1992). |
| Related Vaccine(s) |
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| References |
Boersma et al., 1992: Boersma WJ, Bogaerts WJ, Bianchi AT, Claassen E. Adjuvant properties of stable water-in-oil emulsions: evaluation of the experience with Specol. Research in immunology. 1992; 143(5); 503-512. [PubMed: 1439130].
Vogel and Powell, 1995: Vogel FR, Powell MF. A compendium of vaccine adjuvants and excipients. Pharmaceutical biotechnology. 1995; 6; 141-228. [PubMed: 7551218].
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