NS-TLR |
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Vaxjo ID |
403 |
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Vaccine Adjuvant Name |
NS-TLR |
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Alternative Names |
NS-TLR may be referred to as nanoshell-TLR7 conjugates. |
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Adjuvant VO ID |
VO_0005685
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Description |
NS-TLR consists of silica nanoshells conjugated with a small-molecule TLR7 agonist (1V209), designed to enhance immune responses by activating TLR7 signaling pathways. |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
silica nanoshells-TLR7 conjugates (NS-TLR) depends on nanoshell size and ligand coating density |
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Structure |
NS-TLR is composed of hollow silica nanoshells functionalized with TLR7 agonists on their surface, allowing for targeted immune activation. |
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Preparation |
NS-TLR is prepared by conjugating the TLR7 agonist (1V209) to silica nanoshells through established surface modification techniques. |
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Dosage |
In the studies, NS-TLR was used in formulations with doses of 20 ug of OVA (ovalbumin) as a model antigen. |
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Function |
The results show that the TLR7 ligand conjugated to silica nanoshells is capable of activating an inflammasome pathway to enhance both innate immune-stimulatory and adjuvant potencies of the TLR7 agonist, thereby broadening applications of innate immune stimulators. |
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Safety |
The article indicates that NS-TLR has a low toxicity profile and enhances the immune response without significant adverse effects. |
| References |
Huang et al., 2019: Huang CH, Mendez N, Echeagaray OH, Weeks J, Wang J, Vallez CN, Gude N, Trogler WC, Carson DA, Hayashi T, Kummel AC. Conjugation of a Small-Molecule TLR7 Agonist to Silica Nanoshells Enhances Adjuvant Activity. ACS applied materials & interfaces. 2019; 11(30); 26637-26647. [PubMed: 31276378].
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