Injectable Excipients |
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Vaxjo ID |
397 |
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Vaccine Adjuvant Name |
Injectable Excipients |
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Alternative Names |
they are commonly referred to as adjuvants or drug additives. |
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Adjuvant VO ID |
VO_0005679
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Description |
Injectable excipients are natural or synthetic additives used to enhance the action, solubility, and/or stability of active ingredients in vaccines. In this study, they were screened for their adjuvant effects on influenza vaccines. |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Storage |
The injectable excipients were stored at -20°C until use, except for aluminum hydroxide gel, which was stored at room temperature. |
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Preparation |
The injectable excipients were suspended in phosphate-buffered saline (PBS) and sonicated before use. |
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Dosage |
The excipients were administered at a dosage of 100 mg/dose, with specific exceptions noted for ethanol. |
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Function |
Of these 46 candidates, we identified 20 compounds that enhanced the efficacy of the split influenza HA vaccine against lethal virus challenge. These 20 compounds included 15 novel adjuvant candidates and 5 compounds with previously reported adjuvant effects for other antigens but not for influenza vaccine. |
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Safety |
The injectable excipients are considered safe as they are already approved for human use and have good safety profiles. |
| References |
Feng et al., 2019: Feng H, Yamashita M, da Silva Lopes TJ, Watanabe T, Kawaoka Y. Injectable Excipients as Novel Influenza Vaccine Adjuvants. Frontiers in microbiology. 2019; 10; 19. [PubMed: 30733711].
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