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CL429 |
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Vaxjo ID |
389 |
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Vaccine Adjuvant Name |
CL429 |
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Alternative Names |
CL429 is a chimeric adjuvant containing components that stimulate TLR2 and NOD2. |
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Adjuvant VO ID |
VO_0005671
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Description |
CL429 is a covalently linked chimeric adjuvant that combines the agonists Pam2C (a TLR2 agonist) and murabutide (a NOD2 agonist). It is designed to enhance immune responses when used in vaccines. |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Preparation |
CL429 is prepared by chemically linking the TLR2 and NOD2 agonists, but specific preparation methods are not provided. |
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Function |
CL429, a TLR2 and NOD2 agonist known to mimic the modulatory effect of Lactobacillus, alleviated acute leptospiral infection |
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Safety |
CL429 has shown enhanced immunogenicity and safety in preclinical studies, but specific safety data in clinical trials are not detailed in the article. |
| References |
Tom et al., 2019: Tom JK, Albin TJ, Manna S, Moser BA, Steinhardt RC, Esser-Kahn AP. Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development. Trends in biotechnology. 2019; 37(4); 373-388. [PubMed: 30470547].
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