PAMK |
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Vaxjo ID |
381 |
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Vaccine Adjuvant Name |
PAMK |
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Alternative Names |
Polysaccharides of Atractylodes macrocephala Koidz |
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Adjuvant VO ID |
VO_0005663
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Description |
PAMK is a natural polysaccharide derived from the roots of the traditional Chinese medicinal herb Atractylodes macrocephala. It is known for its immunopotentiation properties. |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
Polysaccharides of Atractylodes macrocephala Koidz (PAMK) |
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Structure |
The structure of PAMK consists of various monosaccharides, including rhamnose, xylose, arabinose, glucose, mannose, and galactose, in specific ratios. The average molecular weight is approximately 19.6 * 10^3 Da. |
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Appearance |
The appearance of PAMK is not explicitly described in the article, but it is typically a powder or suspension. |
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Preparation |
PAMK is prepared from the roots of Atractylodes macrocephala and can be loaded into nanostructured lipid carriers (NLC) for enhanced delivery. |
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Function |
the effect of PAKM-NLC on the surface molecule expression of bone marrow-derived dendritic cells (BMDCs) in vitro was investigated by flow cytometry, and the cytokines secreted by dendritic cell supernatants were detected by ELISA |
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Safety |
The article indicates that PAMK has low toxicity and is considered safe for use in vaccine formulations, but specific safety data are not detailed. |
| References |
Liu et al., 2018: Liu Z, Sun Y, Zhang J, Ou N, Gu P, Hu Y, Liu J, Wu Y, Wang D. Immunopotentiation of Polysaccharides of Atractylodes macrocephala Koidz-loaded nanostructured lipid carriers as an adjuvant. International journal of biological macromolecules. 2018; 120(Pt A); 768-774. [PubMed: 30144550].
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