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TRIF

Vaxjo ID 368       
Vaccine Adjuvant Name TRIF       
Adjuvant VO ID VO_0005545
Description genetic adjuvant that induces Th1 response       
Stage of Development Research       
Host Species for Testing Mouse       
Second Host Species for Testing Pig       
Components Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-beta (TRIF)       
Preparation cDNA fragments encoding TLR adaptor molecules were amplified from parental plasmids by PCR and subcloned into the pGA vector       
Function innate immune activation       
References
Takeshita et al., 2006: Takeshita F, Tanaka T, Matsuda T, Tozuka M, Kobiyama K, Saha S, Matsui K, Ishii KJ, Coban C, Akira S, Ishii N, Suzuki K, Klinman DM, Okuda K, Sasaki S. Toll-like receptor adaptor molecules enhance DNA-raised adaptive immune responses against influenza and tumors through activation of innate immunity. Journal of virology. 2006; 80(13); 6218-6224. [PubMed: 16775309].
Wan et al., 2010: Wan C, Yi L, Yang Z, Yang J, Shao H, Zhang C, Pan Z. The Toll-like receptor adaptor molecule TRIF enhances DNA vaccination against classical swine fever. Veterinary immunology and immunopathology. 2010; 137(1-2); 47-53. [PubMed: 20466439].