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Granulysin

Vaxjo ID 363       
Vaccine Adjuvant Name Granulysin       
Adjuvant VO ID VO_0005551
Description TLR4 agonist adjuvant that induces Th1 response       
Stage of Development Research       
Host Species for Testing Mouse       
Components human dimeric soluble form of LAG-3 (hLAG-3-Ig)       
Structure highly cationic and folded as a 5-helix bundle stabilized by 2 highly conserved intramolecular disulfide bonds       
Molecular Weight 9 kDa/15kDa       
Function recruits and activates dendritic cells via TLR4/Myd88       
References
Okada et al., 2011: Okada M, Kita Y, Nakajima T, Kanamaru N, Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Nishimatsu S, Sekine Y, Inoue Y, Matsumoto M, McMurray DN, De la Cruz EC, Tan EV, Abalos RM, Burgos JA, Saunderson P, Sakatani M. Novel therapeutic vaccine: granulysin and new DNA vaccine against Tuberculosis. Human vaccines. 2011; 7 Suppl; 60-67. [PubMed: 21546794].
Zitvogel and Kroemer, 2010: Zitvogel L, Kroemer G. The multifaceted granulysin. Blood. 2010; 116(18); 3379-3380. [PubMed: 21051561].