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VISA |
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Vaxjo ID |
360 |
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Vaccine Adjuvant Name |
VISA |
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Adjuvant VO ID |
VO_0005723
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Description |
adjuvant that induces Th1 response |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
|
Components |
virus-induced signaling adaptor (VISA) from retinoic acid-inducible gene-I (RIG-I) signaling pathway |
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Preparation |
VISA gene fragment was amplified from the pHA-VISA template by PCR using the primers 5′-CTGAAGCTTGACAATGCCGTTT-3′ (sense) and 5′-AGTCTCGAGAGGGCTTCACTAGTG-3′ (anti-sense). The PCR product was first digested using HindIII and XhoI and was then cloned into pVAX1 to generate pVISA |
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Function |
activates NF-κB and IRF3 and thereby leads to the production of type I interferons |
| References |
Luo et al., 2011: Luo M, Qu X, Pan R, Zhu D, Zhang Y, Wu J, Pan Z. The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine. 2011; 29(14); 2561-2567. [PubMed: 21303708].
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