VIOLIN: Vaccine Investigation and Online Information Network

retinoic acid and IL-15
Vaxjo ID	359
Vaccine Adjuvant Name	retinoic acid and IL-15
Adjuvant VO ID	VO_0005557
Description	combination adjuvant that induces mixed Th1/Th17 response
Stage of Development	Research
Host Species for Testing	Mouse
Components	retinoic acid and IL-15
Function	retinoic acid rapidly activates dendritic cells to induce JNK (also known as MAPK8) phosphorylation and release the proinflammatory cytokines IL-12p70 and IL-23
References	*DePaolo et al., 2011:* DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, Semrad C, Kupfer SS, Belkaid Y, Guandalini S, Jabri B. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011; 471(7337); 220-224. [PubMed: 21307853].