|
|
L-NAME |
|
Vaxjo ID |
357 |
|
Vaccine Adjuvant Name |
L-NAME |
|
Adjuvant VO ID |
VO_0005559
|
|
Description |
novel adjuvant that induces Th1 response |
|
Stage of Development |
Research |
|
Host Species for Testing |
Mouse |
|
Components |
N-nitro-L: -arginine methyl ester (L-NAME) |
|
Function |
inhibits iNOS (inducible nitric oxide synthase) which allows expansion of CD8+ cells |
| References |
Egilmez et al., 2011: Egilmez NK, Harden JL, Virtuoso LP, Schwendener RA, Kilinc MO. Nitric oxide short-circuits interleukin-12-mediated tumor regression. Cancer immunology, immunotherapy : CII. 2011; 60(6); 839-845. [PubMed: 21387108].
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