|
|
CnB |
|
Vaxjo ID |
356 |
|
Vaccine Adjuvant Name |
CnB |
|
Alternative Names |
calcineurin subunit B |
|
Adjuvant VO ID |
VO_0005574
|
|
Description |
novel adjuvant that induces Th1 response |
|
Stage of Development |
Research |
|
Host Species for Testing |
Mouse |
|
Components |
calcineurin subunit B (CnB) |
|
Molecular Weight |
18–19 kDa |
|
Function |
dendritic cell activation, promotes the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-?, interleukin-12p70 (IL-12 p70), IL-6 and the chemokine IL-8 |
| References |
Hu et al., 2012: Hu M, Su Z, Yin Y, Li J, Wei Q. Calcineurin B subunit triggers innate immunity and acts as a novel Engerix-B HBV vaccine adjuvant. Vaccine. 2012; 30(32); 4719-4727. [PubMed: 22652401].
Li et al., 2011: Li J, Guo J, Su Z, Hu M, Liu W, Wei Q. Calcineurin subunit B activates dendritic cells and acts as a cancer vaccine adjuvant. International immunology. 2011; 23(5); 327-334. [PubMed: 21447603].
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