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IFN-α

Vaxjo ID 355       
Vaccine Adjuvant Name IFN-α       
Adjuvant VO ID VO_0005573
Description cytokine adjuvant that induces Th1 repsonse       
Stage of Development Clinical Trial       
Location Licensed Italy       
Host Species for Testing Human       
Second Host Species for Testing Mouse       
Components pleiotropic cytokine       
Dosage 1 or 3 MU       
Function innate immune activation       
References
Di et al., 2006: Di Pucchio T, Pilla L, Capone I, Ferrantini M, Montefiore E, Urbani F, Patuzzo R, Pennacchioli E, Santinami M, Cova A, Sovena G, Arienti F, Lombardo C, Lombardi A, Caporaso P, D'Atri S, Marchetti P, Bonmassar E, Parmiani G, Belardelli F, Rivoltini L. Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors. Cancer research. 2006; 66(9); 4943-4951. [PubMed: 16651452].
Rizza et al., 2008: Rizza P, Capone I, Urbani F, Montefiore E, Rapicetta M, Chionne P, Candido A, Tosti ME, Grimaldi M, Palazzini E, Viscomi G, Cursaro C, Margotti M, Scuteri A, Andreone P, Taylor E, Haygreen EA, Tough DF, Borrow P, Selleri M, Castilletti C, Capobianchi M, Belardelli F. Evaluation of the effects of human leukocyte IFN-alpha on the immune response to the HBV vaccine in healthy unvaccinated individuals. Vaccine. 2008; 26(8); 1038-1049. [PubMed: 18249478].
Rizza et al., 2011: Rizza P, Capone I, Moretti F, Proietti E, Belardelli F. IFN-α as a vaccine adjuvant: recent insights into the mechanisms and perspectives for its clinical use. Expert review of vaccines. 2011; 10(4); 487-498. [PubMed: 21506646].