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HMGB1 |
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Vaxjo ID |
354 |
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Vaccine Adjuvant Name |
HMGB1 |
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Adjuvant VO ID |
VO_0005622
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Description |
cytokine adjuvant that induces Th1 repsonse |
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Stage of Development |
Research |
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Host Species for Testing |
Mouse |
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Components |
plasmid-encoded high-mobility group box 1 protein (HMGB1) |
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Structure |
High mobility group box 1 (HMGB1) protein is a small 25-kDa protein of 215 amino acids that is highly conserved.17 The HMGB1 molecule is organized into three domains: two DNA-binding domains; HMG box A and box B; and an acidic COOH terminus composed of 30 glutamic and aspartic acid residues |
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Molecular Weight |
25kDa |
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Function |
Type: microbial derivative vaccine adjuvant. Induces Th1-biased immune profile. activate dendritic cells and promote CD8⁺ T cell responses |
| References |
Fagone et al., 2011: Fagone P, Shedlock DJ, Bao H, Kawalekar OU, Yan J, Gupta D, Morrow MP, Patel A, Kobinger GP, Muthumani K, Weiner DB. Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination. Gene therapy. 2011; 18(11); 1070-1077. [PubMed: 21544096].
Muthumani et al., 2009: Muthumani G, Laddy DJ, Sundaram SG, Fagone P, Shedlock DJ, Kannan S, Wu L, Chung CW, Lankaraman KM, Burns J, Muthumani K, Weiner DB. Co-immunization with an optimized plasmid-encoded immune stimulatory interleukin, high-mobility group box 1 protein, results in enhanced interferon-gamma secretion by antigen-specific CD8 T cells. Immunology. 2009; 128(1 Suppl); e612-620. [PubMed: 19740322].
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