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FLIC |
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Vaxjo ID |
353 |
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Vaccine Adjuvant Name |
FLIC |
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Adjuvant VO ID |
VO_0005575
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Description |
TLR5 agonist adjuvant derived from major structural protein of flagellin in salmonella that induces mixed Th1/Th2 response |
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Stage of Development |
Research |
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Host Species for Testing |
Rat |
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Components |
recombinant flagellin protein derived from Salmonella (FliC) |
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Preparation |
flic gene amplified by PCR and cloned into pET30 plasmid vector, |
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Function |
induces mucosal immunity, enhance specific IgA responses in saliva |
| References |
Shi et al., 2012: Shi W, Li YH, Liu F, Yang JY, Zhou DH, Chen YQ, Zhang Y, Yang Y, He BX, Han C, Fan MW, Yan HM. Flagellin enhances saliva IgA response and protection of anti-caries DNA vaccine. Journal of dental research. 2012; 91(3); 249-254. [PubMed: 22027714].
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