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CA-CpG |
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Vaxjo ID |
349 |
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Vaccine Adjuvant Name |
CA-CpG |
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Adjuvant VO ID |
VO_0005270
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Description |
pH-responsive biodegradable nanoparticles that act as CpG ODN delivery vehicles. |
|
Stage of Development |
Research |
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Host Species for Testing |
Mouse |
|
Components |
we demonstrate the potential of pH-responsive biodegradable carbonate apatite (CA) nanoparticles as CpG ODN delivery vehicles that can enhance the production of type-I IFNs (such as IFN-脦卤) relative to that induced by CpG ODNs and can augment the adjuvant effects of CpG ODNs in vivo. |
|
Structure |
Nanoparticles |
|
Function |
we demonstrate the potential of pH-responsive biodegradable carbonate apatite (CA) nanoparticles as CpG ODN delivery vehicles that can enhance the production of type-I IFNs (such as IFN-娄脕) relative to that induced by CpG ODNs and can augment the adjuvant effects of CpG ODNs in vivo. |
| Related Vaccine(s) |
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| References |
Takahashi et al., 2018: Takahashi H, Misato K, Aoshi T, Yamamoto Y, Kubota Y, Wu X, Kuroda E, Ishii KJ, Yamamoto H, Yoshioka Y. Carbonate Apatite Nanoparticles Act as Potent Vaccine Adjuvant Delivery Vehicles by Enhancing Cytokine Production Induced by Encapsulated Cytosine-Phosphate-Guanine Oligodeoxynucleotides. Frontiers in immunology. 2018; 9; 783. [PubMed: 29720976].
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