AlO(OH)-polymer nanoparticles |
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Vaxjo ID |
344 |
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Vaccine Adjuvant Name |
AlO(OH)-polymer nanoparticles |
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Adjuvant VO ID |
VO_0005527
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Description |
Aluminum hydroxide is a classical gel-like immune adjuvant. The paper describes AlO(OH)-polymer nanoparticles (APNs), which are nano-sized vaccine carriers derived from aluminum hydroxide, designed to promote lymphatic migration and amplify CD8+ T cell responses. |
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Stage of Development |
Licensed |
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Host Species for Testing |
Human |
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Structure |
The classical adjuvant is described as "gel-like". The new formulation is "nano-sized vaccine carriers AlO(OH)-polymer nanoparticles (APNs)". |
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Appearance |
The classical adjuvant is described as "gel-like". |
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Preparation |
Aluminum hydroxide is "turned from gel into nano-sized vaccine carriers AlO(OH)-polymer nanoparticles (APNs)". |
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Function |
aluminum hydroxide is turned from gel into nano-sized vaccine carriers AlO(OH)-polymer nanoparticles (APNs) to promote their lymphatic migration. |
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Safety |
Aluminum hydroxide has been used as an immune adjuvant in human vaccines for over 80 years due to its safety and efficacy. |
| References |
Jiang et al., 2018: Jiang H, Wang Q, Li L, Zeng Q, Li H, Gong T, Zhang Z, Sun X. Turning the Old Adjuvant from Gel to Nanoparticles to Amplify CD8(+) T Cell Responses. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2018; 5(1); 1700426. [PubMed: 29375970].
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