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MDA5 |
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Vaxjo ID |
338 |
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Vaccine Adjuvant Name |
MDA5 |
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Adjuvant VO ID |
VO_0005583
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Description |
genetic adjuvant consisting of melanoma differentiation-associated gene 5 product (chMDA5) that induces a Th1 response |
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Stage of Development |
Research |
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Host Species for Testing |
Chicken |
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Components |
melanoma differentiation-associated gene 5 product (chMDA5) |
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Structure |
N-terminal 483 amino acids of the chicken MDA5 |
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Function |
innate immune activation |
| References |
Liniger et al., 2012: Liniger M, Summerfield A, Ruggli N. MDA5 can be exploited as efficacious genetic adjuvant for DNA vaccination against lethal H5N1 influenza virus infection in chickens. PloS one. 2012; 7(12); e49952. [PubMed: 23227156].
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