|
|
Graphene oxide |
|
Vaxjo ID |
337 |
|
Vaccine Adjuvant Name |
Graphene oxide |
|
Adjuvant VO ID |
VO_0005585
|
|
Description |
adjuvant derived from graphene that induces a Th1 response |
|
Stage of Development |
Research |
|
Host Species for Testing |
Mouse |
|
Components |
Graphene oxide |
|
Function |
enhances the secretion of macrophages by activating the NF-kB signaling pathway, and activates the immune system by promoting the proliferation and differentiation of lymphocytes (especially CD8+T cells) and the secretion of inflammatory mediators |
|
Safety |
dose-dependent toxicity to cells and animals, such as inducing cell apoptosis and lung granuloma formation |
| References |
Bai et al., 2022: Bai Q, Wang Z, An Y, Tian J, Li Z, Yang Y, Dong Y, Chen M, Liu T. Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine. Vaccine. 2022; 40(52); 7613-7621. [PubMed: 36371365].
Zhi et al., 2013: Zhi X, Fang H, Bao C, Shen G, Zhang J, Wang K, Guo S, Wan T, Cui D. The immunotoxicity of graphene oxides and the effect of PVP-coating. Biomaterials. 2013; 34(21); 5254-5261. [PubMed: 23566800].
|
|
