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Alum and IL-10 |
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Vaxjo ID |
335 |
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Vaccine Adjuvant Name |
Alum and IL-10 |
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Adjuvant VO ID |
VO_0005528
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Description |
Alum is a vaccine adjuvant that promotes IL-10 production, which suppresses Th1 responses, and facilitates the induction of neutralizing antibodies. |
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Stage of Development |
Licensed |
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Location Licensed |
many places |
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Components |
Injection of alum primed draining lymph node cells for enhanced IL-10 secretion ex vivo |
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Function |
these findings indicate that injection of alum promotes IL-10, which can block Th1 responses and may explain the poor efficacy of alum as an adjuvant for inducing protective Th1 immunity. |
| References |
Oleszycka et al., 2018: Oleszycka E, McCluskey S, Sharp FA, Muñoz-Wolf N, Hams E, Gorman AL, Fallon PG, Lavelle EC. The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses. European journal of immunology. 2018; 48(4); 705-715. [PubMed: 29349774].
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