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TDM |
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Vaxjo ID |
325 |
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Vaccine Adjuvant Name |
TDM |
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Adjuvant VO ID |
VO_0005587
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Description |
oil in water emulsion adjuvant that induces Th1 response |
|
Stage of Development |
Research |
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Host Species for Testing |
Mouse |
|
Components |
mycobacterial lipid, 6,6′-trehalose dimycolate (TDM) |
|
Function |
innate immune activation |
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Safety |
toxic at high doses- can lead to formation of granulomas depending on species |
| References |
Carlétti et al., 2013: Carlétti D, Morais da Fonseca D, Gembre AF, Masson AP, Weijenborg Campos L, Leite LC, Rodrigues Pires A, Lannes-Vieira J, Lopes Silva C, Bonato VL, Horn C. A single dose of a DNA vaccine encoding apa coencapsulated with 6,6'-trehalose dimycolate in microspheres confers long-term protection against tuberculosis in Mycobacterium bovis BCG-primed mice. Clinical and vaccine immunology : CVI. 2013; 20(8); 1162-1169. [PubMed: 23740922].
Miyake et al., 2013: Miyake Y, Toyonaga K, Mori D, Kakuta S, Hoshino Y, Oyamada A, Yamada H, Ono K, Suyama M, Iwakura Y, Yoshikai Y, Yamasaki S. C-type lectin MCL is an FcRγ-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity. 2013; 38(5); 1050-1062. [PubMed: 23602766].
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